{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T07:09:12Z","timestamp":1788764952144,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":248,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Leprosy and American cutaneous leishmaniasis are endemic diseases in Brazil that may coexist in the same host, particularly in coendemic regions. We report the case of a 68\u2010year\u2010old woman presenting with a six\u2010month history of an ulcerated lesion on the left knee and concomitant disseminated annular plaques associated with sensory loss, madarosis, and peripheral nerve thickening. Histopathological examination of the ulcer demonstrated findings compatible with cutaneous leishmaniasis; immunohistochemistry using CD1a highlighted structures compatible with amastigotes, acknowledging its limitations. Biopsy of the plaques revealed a chronic granulomatous dermatitis with numerous acid\u2010fast bacilli, corroborating multibacillary leprosy in the appropriate clinical context. The patient was treated with multidrug therapy for leprosy and intralesional meglumine antimoniate for leishmaniasis, with favorable outcomes. To the best of our knowledge, this is the first published report of such coinfection in Cear\u00e1. This case highlights the importance of sampling lesions with distinct morphologies and integrating clinical, histopathological, and laboratory findings in endemic settings.<\/jats:p>","DOI":"10.1155\/carm\/3062648","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T06:40:01Z","timestamp":1788763201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coinfection of Leprosy and American Cutaneous Leishmaniasis: A Case Report From Cear\u00e1, Brazil"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5726-0274","authenticated-orcid":false,"given":"Moacir Pereira Leite","family":"Neto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7867-9566","authenticated-orcid":false,"given":"Jordannia Oliveira","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0484-8956","authenticated-orcid":false,"given":"Ana Carolina Carvalho","family":"Ferraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8977-5299","authenticated-orcid":false,"given":"Julia Graziele Alves","family":"Marelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8127-7308","authenticated-orcid":false,"given":"Marcos Ant\u00f4nio Pereira de","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5730-0512","authenticated-orcid":false,"given":"Cl\u00e1udio Gleidiston Lima da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4941-408X","authenticated-orcid":false,"given":"Ligia Regina Franco Sansigolo","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9651-3713","authenticated-orcid":false,"given":"Ricardo Queiroz","family":"Gurgel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"key":"e_1_2_11_1_2","volume-title":"Department of Strategic Coordination of Health Surveillance. Health Surveillance Guide","author":"Brazil Ministry of Health Health Surveillance Secretariat","year":"2022"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-9946202567074"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.103563"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.685296"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/376632"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20186698"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0172-2018"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.16-0622"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010035"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1590\/s1678-9946201658086"},{"key":"e_1_2_11_11_2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-3-030-67452-6_8","article-title":"Pathogenesis and Host Immune Response in Leprosy","volume":"1313","author":"Yasmin H.","year":"2021","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/immuno2010015"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-08632-6"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1586\/eri.10.19"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-9946201961025"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000002867"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13040"},{"key":"e_1_2_11_18_2","first-page":"173","article-title":"Hansen\u00edase: Diagn\u00f3stico e Tratamento","volume":"19","author":"Last\u00f3ria J. C.","year":"2014","journal-title":"Diagn\u00f3stico & Tratamento"},{"key":"e_1_2_11_19_2","first-page":"433","article-title":"Cutaneous Ulcers in Leprosy: Clinical and Epidemiological Profile of Patients","volume":"82","author":"Gomes F. G.","year":"2007","journal-title":"Anais Brasileiros de Dermatologia"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-023-00674-4"},{"key":"e_1_2_11_21_2","first-page":"1637","article-title":"The Immunoperoxidase Technique Using Polyclonal Anti-Leishmania Antibody in the Diagnosis of American Tegumentary Leishmaniasis","volume":"120","author":"Menezes J. P. B.","year":"2021","journal-title":"Parasitology Research"},{"key":"e_1_2_11_22_2","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1086\/427069","article-title":"Differential Interferon-Gamma Production Characterizes Cytokine Responses to Leishmania and Mycobacterium leprae Antigens in Concomitant Mucocutaneous Leishmaniasis and Lepromatous Leprosy","volume":"40","author":"Matos D. S.","year":"2005","journal-title":"Clinical Infectious Diseases"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0100-879x2012007500073"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carm\/3062648","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/carm\/3062648","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carm\/3062648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T06:40:04Z","timestamp":1788763204000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/carm\/3062648"}},"subtitle":[],"editor":[{"given":"Semonti","family":"Nandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/carm\/3062648"],"URL":"https:\/\/doi.org\/10.1155\/carm\/3062648","archive":["Portico"],"relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"value":"1687-9627","type":"print"},{"value":"1687-9635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3062648"}}