{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:21:06Z","timestamp":1787556066529,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":234,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Renal cell carcinoma (RCC) with fibromyomatous stroma (RCC\u2010FMS) was classified as an \u201cemerging\/provisional\u201d entity in the 2016 WHO classification of tumors, specifically categorized as RCC with (vascular) fibromyomatous stroma. However, it was not included in the 2022 WHO classification. Renal cell carcinoma with hemangioblastoma (RCC\u2010HB)\u2010like features has also been reported infrequently in recent years. RCC\u2010HB\u2010like features and fibromyomatous stroma is quite rare, with only two reports in the literature. This report describes a rare tumor of RCC\u2010HB\u2010like features and fibromyomatous stroma associated with TSC1 mutations. A female patient was incidentally discovered a right renal mass during a routine physical examination conducted 2\u2009weeks prior. Histology revealed that the tumor consisted of three distinct components: clear cell papillary renal cell tumor (CCPRCT)\u2010like areas, fibromyomatous stroma, and HB\u2010like areas. Immunohistochemical staining showed that the CCPRCT\u2010like components exhibited basolateral, cup\u2010shaped CAIX staining and were diffusely positive for AE1\/AE3, CK7, and PAX\u20108, partially positive for AMACR\/P504S, and weakly positive for CD10. The fibromyomatous stroma was positive for H\u2010caldesmon, desmin, and SMA. In the HB\u2010like components, \u03b1\u2010inhibin, ERG, CD34, CAIX, and vimentin were all diffusely positive, CD10 was partially positive, and PAX\u20108 showed scattered, weak positivity. Whether RCC\u2010HB features and fibromyomatous stroma can be regarded as a distinct subtype of RCC remains to be discussed by accumulation of more cases.<\/jats:p>","DOI":"10.1155\/carm\/3548941","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:46:11Z","timestamp":1787553971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Renal Cell Carcinoma With Hemangioblastoma\u2010Like Features, Fibromyomatous Stroma, and TSC1 Mutation"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5296-7699","authenticated-orcid":false,"given":"Shiyun","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfa","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1617-1769","authenticated-orcid":false,"given":"Chunji","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-022-02844-3"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/pas.0b013e3181f2d9b8"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-022-01213-8"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.47102"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.04.022"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4103\/0377-4929.162898","article-title":"Clear Cell Renal Cell Carcinoma with Hemangioblastoma-like Features: a Recently Described Pattern with Unusual Immunohistochemical Profile","volume":"58","author":"Sancheti S.","year":"2015","journal-title":"Indian Journal of Pathology & Microbiology"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/pas.0000000000001255"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.06.016"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2022.12.015"},{"key":"e_1_2_7_10_2","first-page":"726","article-title":"Renal Cell Carcinoma with Hemangioblastoma-like Features and Leiomyomatous Stroma: A Clinicopathological Analysis","volume":"27","author":"Chen Y. Y.","year":"2020","journal-title":"Chinese Journal of Diagnostic Pathology"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/pas.0000000000001422"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.15505"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-025-04325-w"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.70003"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes12101585"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carm\/3548941","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/carm\/3548941","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carm\/3548941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:46:12Z","timestamp":1787553972000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/carm\/3548941"}},"subtitle":[],"editor":[{"given":"Anand","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/carm\/3548941"],"URL":"https:\/\/doi.org\/10.1155\/carm\/3548941","archive":["Portico"],"relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"value":"1687-9627","type":"print"},{"value":"1687-9635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3548941"}}