{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:32:19Z","timestamp":1786613539675,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":224,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Guillain\u2013Barr\u00e9 syndrome (GBS) is an immune\u2010mediated disorder of the peripheral nervous system characterized by progressive weakness and often triggered by infections. GBS has an estimated mortality rate of approximately 5%, with a worldwide incidence of 0.81\u20131.91 cases per 1,00,000 person\u2010years. This case reported a 23\u2010year\u2010old man presented with progressive weakness in all four extremities. An initial neurological examination revealed bilateral total ophthalmoplegia, ptosis on both eyes, bilateral facial palsy lower motor neuron (LMN) type, dysarthria, dysphagia, flaccid tetra\u2010paresis, gloves, and stocking paresthesia. Lumbar puncture showed cytoalbumin dissociation. Nerve conduction studies showed a demyelinating sensorimotor polyradiculoneuropathy lesion. The patient received intravenous immunoglobulin (IVIG) treatment 0.4\u2009g\/kg\/day for 5\u2009days, physical rehabilitation therapy, nutritional support, multidisciplinary care involving anesthesiology and intensive care teams, and other symptomatic treatments. At five\u2010month follow\u2010up, the patient demonstrated complete recovery. GBS typically presents as an acute ascending sensorimotor neuropathy; however, atypical presentations may occur. Extensive cranial nerve involvement\u2014including complete ophthalmoplegia, bilateral facial palsy, and bulbar dysfunction\u2014in AIDP is uncommon and may mimic other GBS spectrum disorders. Early recognition, prompt immunotherapy, and careful electrophysiological evaluation are essential for optimizing patient outcomes. Because electrodiagnostic classification of GBS may evolve over time, serial nerve conduction studies should be considered whenever feasible to improve subtype classification and diagnostic confidence.<\/jats:p>","DOI":"10.1155\/carm\/3658834","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:22:23Z","timestamp":1786612943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Inflammatory Demyelinating Polyradiculoneuropathy Presenting With Multiple Cranial Nerve Palsies and Total Ophthalmoplegia: The Importance of Accurate Diagnosis and Timely Immunotherapy"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1359-9379","authenticated-orcid":false,"given":"Niswah Silmi","family":"Fatimah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0369-0898","authenticated-orcid":false,"given":"Abdulloh","family":"Machin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0250-9"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.142"},{"key":"e_1_2_12_3_2","article-title":"Guillain-Barr\u00e9 Syndrome Associated With COVID-19 Vaccination","volume":"1","author":"Shao S.-C.","year":"2021","journal-title":"The Lancet Microbe"},{"key":"e_1_2_12_4_2","article-title":"Guillain\u2013Barr\u00e9 syndrome","author":"Ario Mirian M. D. M. Sc","year":"2021","journal-title":"Canadian Medical Association Journal"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(21)00517-1"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087288"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-307815"},{"key":"e_1_2_12_8_2","article-title":"Frequency of Cranial Nerve Involvement in Patients With Guillain-Barre syndrome Frequency of Cranial Nerve Involvement in Patients With Guillain-Barre syndrome Address for Correspondence","volume":"11","author":"Suhail R.","year":"2015","journal-title":"Pakistan Institute of Medical Sciences"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-300309"},{"key":"e_1_2_12_10_2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4274\/tnd.2020.60948","article-title":"Twelfth Cranial Nerve Involvement in Guillain-Barre syndrome: A Case Report","volume":"26","author":"\u00c7ifter G.","year":"2020","journal-title":"Turkish Journal of Neurology"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.4103\/0976-3147.145200"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12594"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carm\/3658834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/carm\/3658834","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carm\/3658834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:22:25Z","timestamp":1786612945000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/carm\/3658834"}},"subtitle":[],"editor":[{"given":"Priya","family":"Gusain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/carm\/3658834"],"URL":"https:\/\/doi.org\/10.1155\/carm\/3658834","archive":["Portico"],"relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"value":"1687-9627","type":"print"},{"value":"1687-9635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3658834"}}