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Contrast\u2010enhanced brain MRI revealed a solitary, contrast\u2010enhancing mass in the right head of the caudate nucleus with extensive perifocal edema, raising a primary differential diagnosis of glioblastoma versus metastasis, among other possibilities. Prior to surgical removal of the suspected glioblastoma, the patient underwent additional diffusion tensor imaging and research MRI, including multifrequency magnetic resonance elastography (MRE) to generate mechanical property maps of stiffness and tissue viscosity and to potentially differentiate between glioma, brain metastases, and benign masses based on tissue biomechanical properties. MRE revealed abnormally high values of stiffness and viscosity\u2014a mechanical signature known to be associated with brain metastases or meningioma, but not glioblastoma, which typically exhibits soft tissue properties with reduced viscous dissipation. Histopathologic evaluation confirmed MRE by revealing a distant metastasis of squamous cell carcinoma, the primary tumor of which was detected by PET\u2010CT within the right hilus of the lung. This case demonstrates the diagnostic value of the biomechanical properties of brain tumors and raises the prospect of applying MRE as an easy\u2010to\u2010use MRI contrast that can rule out glioma when the suspicious lesion exhibits stiff\u2010viscous material properties.<\/jats:p>","DOI":"10.1155\/carm\/3863128","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:16:09Z","timestamp":1782296169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stiffness and Tissue Viscosity in a Cerebral Neoplasm Measured by Preoperative Multifrequency Magnetic Resonance Elastography (MRE) Guide the Differential Diagnosis of Brain Tumors by Ruling Out 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