{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:54Z","timestamp":1787017794566,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Schistosomiasis is one of the neglected tropical diseases caused by parasitic worm infections of the genus\n                    <jats:italic>Schistosoma<\/jats:italic>\n                    . Involvement of the brain in schistosomiasis represents a particularly severe manifestation of the infection. Accurate diagnosis and appropriate treatment of cerebral schistosomiasis are essential, especially in our healthcare facility located in a remote area of Indonesia, where available resources are highly limited. We reported a 31\u2010year\u2010old female patient complaining of tonic\u2010clonic convulsions. Before experiencing seizures, the patient reported experiencing headaches for 6\u2009months. The patient\u2019s anamnesis regarding her social life revealed that she has been employed on a plantation for 15\u2009years; the plantation serves as a natural habitat for snails, intermediate hosts for\n                    <jats:italic>Schistosoma<\/jats:italic>\n                    sp. Serological examinations were not performed due to the constraints of diagnostic instruments in the region. Cerebral schistosomiasis diagnosis was verified based on biopsy, stool examination, and CT scan results. She was admitted with a combination of steroids and praziquantel at a dosage of 60\u2009mg\/kg single dose. She was released after 14\u2009days in satisfactory overall health. The follow\u2010up CT scan revealed improvement, corroborated by the patient\u2019s clinical recovery. This report emphasizes the diagnostic obstacles associated with cerebral schistosomiasis, particularly in remote regions and resource\u2010limited settings in Indonesia. Despite the absence of serological testing, a definitive diagnosis was successfully established through radiological imaging, stool microscopic examination, and brain tissue biopsy (histopathological analysis) which revealed\n                    <jats:italic>Schistosoma<\/jats:italic>\n                    eggs surrounded by granulomatous inflammation. The patient presented with space\u2010occupying brain lesions and neurological symptoms, but without hepatic involvement, making the diagnosis less straightforward. This case illustrates the significance of recognizing cerebral schistosomiasis as a differential diagnosis in patients presenting cerebral lesions in endemic locations. Diagnosis of cerebral schistosomiasis based on a detailed social occupational history correlated with radiological imaging, stool microscopic examination, and brain tissue biopsy (histopathological analysis) is essential when other diagnostic tools (serological testing) are unavailable.\n                  <\/jats:p>","DOI":"10.1155\/carm\/4781807","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T07:49:57Z","timestamp":1751356197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cerebral Schistosomiasis in the Napu Valley, Central Sulawesi, Indonesia"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8527-4953","authenticated-orcid":false,"given":"Prawesty Diah","family":"Utami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6338-4024","authenticated-orcid":false,"given":"Yunita Surya","family":"Pratiwi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7560-9289","authenticated-orcid":false,"given":"Retno","family":"Budiarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3539-5682","authenticated-orcid":false,"given":"Wienta","family":"Diarsvitri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2542-5196(20)30129-7"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010389"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1812165"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2019.06.001"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed7110354"},{"key":"e_1_2_11_6_2","volume-title":"Schistosomiasis","author":"World Health Organization","year":"2023"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0013-8"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae074"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228770"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-021-00919-z"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2923-6"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.574136"},{"key":"e_1_2_11_13_2","volume-title":"Overcoming Challenges to Eliminate Schistosomiasis in Central Sulawesi","author":"Diptyanusa A.","year":"2023"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.2991\/978-94-6463-112-8_85"},{"key":"e_1_2_11_15_2","volume-title":"The Last Miles in Indonesia\u2019s Schistosomiasis Elimination Programm","author":"World Health Organization","year":"2022"},{"key":"e_1_2_11_16_2","volume-title":"Schistosomiasis","author":"Centers for Disease Control and Prevention","year":"2024"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebcr.2014.01.006"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10020205"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.29245\/2689-9981\/2018\/1.1134"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.45418"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-021-02828-z"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01073-11"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.07.002"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.5603\/imh.99453"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.6.1008"},{"key":"e_1_2_11_26_2","article-title":"Neuroschistosomiasis","author":"Elsbernd P. M.","year":"2020","journal-title":"Practical Neurology"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.04.2009.1787"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sciaf.2024.e02165"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.15406\/jmen.2023.11.00389"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.20473\/jops.v9i1.62395"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/9968155"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S391017"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.4103\/LJMS.LJMS_66_19"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1502627"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652005000400001"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3902570"},{"key":"e_1_2_11_37_2","doi-asserted-by":"crossref","unstructured":"RissardoP. J. ByrojuV. V. andCapraraA. L. F. Neuroschistosomiasis: A Narrative Review of a Multifaceted Nature of a Neglected Tropical Disease 2024 https:\/\/doi.org\/10.20944\/preprints202412.0822.v1.","DOI":"10.20944\/preprints202412.0822.v1"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpara.2024.1471451"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2022.111531"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180926145537"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.18483\/ijsci.2103"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carm\/4781807","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/carm\/4781807","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carm\/4781807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:57:17Z","timestamp":1773770237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/carm\/4781807"}},"subtitle":[],"editor":[{"given":"Mona Gamal","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/carm\/4781807"],"URL":"https:\/\/doi.org\/10.1155\/carm\/4781807","archive":["Portico"],"relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"value":"1687-9627","type":"print"},{"value":"1687-9635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4781807"}}