{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T21:31:16Z","timestamp":1773783076303,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":77,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Cerebral metastases from soft tissue and bone sarcoma are uncommon. Metastatic sarcoma of the brain is a highly aggressive disease with a poor prognosis. There is no consensus regarding the management of cerebral metastases from bone sarcomas.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Clinical Presentation:<\/jats:bold>\n                    The patient is a 60\u2010year\u2010old, right\u2010handed male, who presented with a right frontal scalp swelling that was hard in consistency. On examination, he had pain and tenderness over the swelling. The neurological examination was normal.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Investigations:<\/jats:bold>\n                    Initial CTH revealed a right frontal skull lesion with characteristic expansion and sunburst appearance with a degree of cortical destruction. MRI brain with contrast showed features suggestive of skull osteosarcoma.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Management:<\/jats:bold>\n                    He underwent a subtotal tumor resection. He was diagnosed with high\u2010grade chondroblastoma\u2010like osteosarcoma of the skull. Subsequently, he received three cycles of neoadjuvant chemotherapy in the form of Adriamycin and cisplatin. One year later, he underwent further surgical intervention with an additional skull resection and reconstruction using mesh and scalp reconstruction.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Follow-Up:<\/jats:bold>\n                    MRI brain with contrast showed a distant metastasis in the right transverse sinus and other distant brain areas and were treated with Gamma Knife radiosurgery (GKRS) 6\u2009months after the primary surgery.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Skull calvarium primary osteosarcoma is a rare pathology. Cerebral metastasis from skull bone osteosarcoma is a challenging clinical situation that requires a multidisciplinary therapeutic approach that includes neurosurgery, plastic surgery, chemotherapy, and radiosurgery.\n                  <\/jats:p>","DOI":"10.1155\/carm\/5412921","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T03:35:02Z","timestamp":1742355302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Calvarial Chondroplastic Osteosarcoma With Distant Brain Metastasis Treated With Radiosurgery: A Rare Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3934-0470","authenticated-orcid":false,"given":"Mohammed A.","family":"Azab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Hazim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nour","family":"El-Gohary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Nabih Shama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brahim","family":"Kammoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq223"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/2013.12.peds13359"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/scs.0b013e318231fe9b"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850901)56:5<1214::AID-CNCR2820560543>3.0.CO;2-8"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930401)71:7<2210::AID-CNCR2820710708>3.0.CO;2-W"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0136"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.32.15_suppl.10591"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.15376"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0604-2"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010201)91:3<598::AID-CNCR1040>3.0.CO;2-D"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199709)19:6<513::AID-HED9>3.0.CO;2-1"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-020-01740-8"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-0085-0"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.3171\/2008.4.17505"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30589"},{"key":"e_1_2_10_16_2","article-title":"Stereotactic Radiosurgery in the Treatment of Sarcoma Brain Metastasis","volume":"2","author":"Ohla V.","year":"2014","journal-title":"JSM Neurosurg Spine"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.3171\/2023.5.focus23168"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol31110516"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2014.07.039"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-004-4840-y"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.jcrt_654_22"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.08.016"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/475175"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5559-7"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-015-9713-6"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0090-3019(97)00034-7"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1130-1473(01)70671-9"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199503000-00036"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0221-0363(08)71457-4"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-200209000-00009"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13071099"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.21.02314"},{"key":"e_1_2_10_33_2","first-page":"936","article-title":"Outcome Variation Among \u201cradioresistant\u201d Brain Metastases Treated with Stereotactic Radiosurgery","volume":"56","author":"Chang E. 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