{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:57:35Z","timestamp":1790409455640,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"vor","delay-in-days":185,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Female fertility decline with age presents a challenge to successful IVF outcomes. The rising trend of delayed family planning due to societal changes has led to increased demand for reproductive assistance among older women. Despite clinical and scientific advances in Assisted Reproductive Technology, age remains a barrier to successful outcomes mainly due to declining oocyte quality and quantity, leading to decreased fecundity rates and increased miscarriage risks. This report highlights an exceptional case of a women aged 46 achieving live birth through IVF using her own oocytes. Notably, awareness among women about the profound effect of age on fertility remains insufficient. Educating women about these age\u2010related reproductive challenges is crucial. Oocyte cryopreservation emerges as a potential strategy, while egg donation stands as a pragmatic alternative. However, the probability of live birth among women at the extremes of reproductive age using their own oocytes is low, at 0.3%. It is important to approach this case report with caution to avoid unrealistic expectations among women aged 45 or older seeking IVF services.<\/jats:p>","DOI":"10.1155\/carm\/5531403","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T05:05:14Z","timestamp":1751691914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Rare Case of Live Birth Through In Vitro Fertilization in a 46\u2010Year\u2010Old Woman Using Her Autologous Oocytes: Case Report and Literature Review"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3003-3439","authenticated-orcid":false,"given":"Hossam","family":"Elzeiny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,5]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa204"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2020.06.012"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.11.004"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-023-01151-z"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1121231"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des409"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211150"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq360"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav7321"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(00)00518-5"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.09.056"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1472-6483(10)61139-x"},{"key":"e_1_2_10_13_2","first-page":"209","article-title":"Successful Pregnancy Following In Vitro Fertilization Embryo Transfer in a 46\u2009Year-Old Woman With Diminished Oocyte Reserve as Evidenced by a High Day 3 Serum Estradiol","volume":"38","author":"Check J. 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