{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:38:28Z","timestamp":1789465108912,"version":"build-2803163510"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":257,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Hidradenoma papilliferum (HP) is a rare, benign neoplasm classically originating from apocrine or mammary\u2010like glands. While predominantly presenting in the vulvar region, its occurrence in the perianal location is exceptionally rare and frequently misdiagnosed as hemorrhoidal disease or other localized benign lesions. We present the case of a 50\u2010year\u2010old female patient reporting acute perianal pain following defecation straining, accompanied by the sensation of an asymptomatic perianal mass present for three years. Clinical examination identified a 1.5\u2009cm well\u2010circumscribed, reddish\u2010brown nodule at the anal verge. Excisional biopsy was performed under local anesthesia with 1\u2009cm margins, allowing the wound to heal by secondary intention. Histopathological evaluation confirmed perianal HP, characterized by an arboriform papillary architecture, a double\u2010layered epithelium, and classic apocrine decapitation secretion without cytological atypia. Complete surgical excision remains the definitive, curative treatment. This case highlights the absolute necessity of histopathological evaluation for atypical, therapy\u2010resistant perianal lesions to avoid diagnostic anchoring and to definitively rule out malignancy.<\/jats:p>","DOI":"10.1155\/carm\/6733314","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:22:23Z","timestamp":1789460543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perianal Hidradenoma Papilliferum Mimicking a Chronic Hemorrhoid: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6014-8427","authenticated-orcid":false,"given":"Cesar Ramon Razuri","family":"Bustamante","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3042-0340","authenticated-orcid":false,"given":"Sof\u00eda Leonor Prado","family":"Cucho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9191-4737","authenticated-orcid":false,"given":"Laura Elizabeth Qui\u00f1ones","family":"Valverde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9578-9909","authenticated-orcid":false,"given":"Angel Luigui Hurtado","family":"Vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6987-5030","authenticated-orcid":false,"given":"Alexis Narvaez","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4203-3890","authenticated-orcid":false,"given":"Gabriel De La Cruz","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.pog.2011.05.010","article-title":"Hidroadenoma Papil\u00edfero Vulvar. Presentaci\u00f3n De Un Caso","volume":"55","author":"Fischer Su\u00e1rez N.","year":"2012","journal-title":"Progresos De Obstetricia Y Ginecolog\u00eda"},{"key":"e_1_2_11_2_2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.patol.2010.09.003","article-title":"Hidradenoma Papil\u00edfero Anal: Presentaci\u00f3n De Un Caso Y Revisi\u00f3n De La Literatura","volume":"43","author":"Queipo Guti\u00e9rrez F. J.","year":"2010","journal-title":"Revista Espa\u00f1ola De Patolog\u00eda"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcol.2017.11.001"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.3393\/ac.2018.08.03"},{"key":"e_1_2_11_5_2","article-title":"Immunohistochemical and Molecular Characteristics of Anogenital Papillary Hidradenomas","author":"Karpathiou G.","year":"2023","journal-title":"American Journal of Dermatopathology"},{"key":"e_1_2_11_6_2","first-page":"39","article-title":"TRPS1 is Consistently Expressed in Hidradenoma Papilliferum","volume":"45","author":"Velthof L.","year":"2026","journal-title":"International Journal of Gynecological Pathology"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2023.2186781"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carm\/6733314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/carm\/6733314","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carm\/6733314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:22:25Z","timestamp":1789460545000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/carm\/6733314"}},"subtitle":[],"editor":[{"given":"Andee Dzulkarnaen","family":"Zakaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/carm\/6733314"],"URL":"https:\/\/doi.org\/10.1155\/carm\/6733314","archive":["Portico"],"relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"value":"1687-9627","type":"print"},{"value":"1687-9635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6733314"}}