{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T21:31:53Z","timestamp":1773783113290,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":217,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Granuloma annulare (GA) is an inflammatory and granulomatous dermatosis characterized by annular erythematous papules\/plaques frequently localized in acral regions. Proinflammatory cytokines such as tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) and interferon\u2010gamma (IFN\u2010\u03b3), which are released by T helper 1 (Th1) lymphocytes inducing macrophages, are thought to play a role in its pathogenesis. Lichen planus (LP) is an inflammatory dermatosis characterized by pruritic scaly purple papules, often on the wrists and ankles, and can also affect mucosa, hair, and nails. T\u2010cell\u2010mediated proinflammatory cytokines such as IFN\u2010\u03b3 and TNF\u2010\u03b1, which are released by macrophages upon Th1 stimulation, have been implicated in the pathogenesis of LP, as in GA. A new treatment option is needed in the treatment of these diseases due to suboptimal results and adverse side\u2010effect profiles with conventional treatments. Apremilast is a phosphodiesterase\u20104 (PDE4) inhibitor and inhibits the production of various inflammatory mediators such as IFN\u2010\u03b3, TNF\u2010\u03b1, IL\u20102, IL\u20105, IL\u20108, IL\u201012, and leukotriene B4. This molecule has three Food and Drug Administration (FDA) approved indications: moderate to severe plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behcet\u2019s disease. Apremilast exhibits a favorable side\u2010effect profile compared to conventional treatments and is a good treatment option with its ability to reduce cytokines implicated in the pathogenesis of GA and LP. Here, we report the case of a 55\u2010year\u2010old woman in whom apremilast treatment led to an almost complete resolution of her GA and LP.<\/jats:p>","DOI":"10.1155\/carm\/6883705","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:06:36Z","timestamp":1754481996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Patient With Granuloma Annulare and Lichen Planus Treated With Apremilast: A Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2880-3212","authenticated-orcid":false,"given":"Emre","family":"Sar\u0131kaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1216-2253","authenticated-orcid":false,"given":"Meltem","family":"T\u00fcrkmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6061-925X","authenticated-orcid":false,"given":"Selcen","family":"Kundak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1607-500X","authenticated-orcid":false,"given":"S\u00fcmeyye","family":"Ekmekci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_7_1_2","volume-title":"Dermatology","author":"Bolognia J. L.","year":"2008"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(00)90212-3"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.03.054"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.5070\/D341x2d4r2"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.05.056"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12976"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.03.045"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.54.3.229"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10112964"},{"key":"e_1_2_7_10_2","first-page":"53","article-title":"Diagnosis and Treatment of Lichen planus","volume":"84","author":"Usatine R. P.","year":"2011","journal-title":"American Family Physician"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.84474"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00559.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2014.05.014"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-015-0144-3"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carm\/6883705","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/carm\/6883705","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/carm\/6883705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:57:36Z","timestamp":1773770256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/carm\/6883705"}},"subtitle":[],"editor":[{"given":"Shamimul","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/carm\/6883705"],"URL":"https:\/\/doi.org\/10.1155\/carm\/6883705","archive":["Portico"],"relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"value":"1687-9627","type":"print"},{"value":"1687-9635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6883705"}}