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Detection of CD103 expression on flow cytometry is the key in enumerating the immunologic score for diagnosing HCL. For a disease that is more prevalent in Caucasians and less common in African populations, we report an unusual case of CD103\u2010negative classical HCL in a 43\u2010year\u2010old African male, who presented with refractory anemia, thrombocytopenia, and splenomegaly. In patients with refractory anemia, it is crucial to consider investigating HCL, as this may influence therapeutic decisions and, consequently, overall patient outcomes.<\/jats:p>","DOI":"10.1155\/carm\/7084757","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T11:04:20Z","timestamp":1752231860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["CD103\u2010Negative Hairy Cell Leukemia: A Case Report From University Teaching Hospital, Zambia"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2409-4502","authenticated-orcid":false,"given":"Natasha Mupeta","family":"Kaweme","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8255-0799","authenticated-orcid":false,"given":"Sahar Mounir 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