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Anaplastic lymphoma kinase (ALK)\u2010rearranged NSCLC is a rare but increasingly recognized entity in young women, including during pregnancy. Here, we report the case of a 37\u2010year\u2010old woman diagnosed with metastatic ALK\u2010rearranged NSCLC during her first pregnancy, who was commenced on alectinib. Following this, she had a successful second pregnancy whilst being treated with alectinib (withheld during weeks 6\u201310 of gestation to avoid the critical period of organogenesis). Both pregnancies resulted in healthy infants with no complications or evidence of developmental delays. This case highlights the importance of a multidisciplinary approach involving oncology, maternal\u2010fetal medicine, clinical genetics, obstetrics medicine, and obstetrics to balance maternal cancer control and fetal health. While preclinical studies of alectinib suggest teratogenic risks, this and other reported cases demonstrate its potential for safe use during pregnancy with careful planning. Pathological examination of the placenta in our case revealed no malignant cells, and maternal disease remained controlled. As targeted therapies extend survival in advanced NSCLC, more patients may contemplate pregnancy, emphasizing the need for robust evidence to guide treatment decisions. This case contributes to the growing body of evidence supporting the feasibility of managing pregnancy in patients with ALK\u2010rearranged NSCLC using targeted therapies like alectinib, while underscoring the importance of long\u2010term follow\u2010up for the exposed offspring.<\/jats:p>","DOI":"10.1155\/carm\/9032427","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:04:59Z","timestamp":1746849899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Beating the Odds: A Successful Pregnancy in a Patient With ALK\u2010Rearranged Lung Cancer on 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