{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:31:24Z","timestamp":1792211484816,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":139,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Immune checkpoints are molecules that serve to augment or inhibit the immune response. The treatment landscape for numerous tumors now relies significantly on immune checkpoint inhibitors (ICIs). Pembrolizumab, a subset of ICIs specifically focused on the programmed cell death 1 (PD\u20101) molecule. By blocking PD\u20101, these inhibitors enhance the ability of the immune system to fight cancer cells. Although PD\u20101 inhibitors are critical in cancer treatment, their use can be associated with immune\u2010related adverse events, such as ICI\u2010related sarcoid\u2010like reaction.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case Presentation:<\/jats:bold>\n                    This report describes a 49\u2010year\u2010old female patient with stage IIIA breast cancer breast cancer who developed ICI\u2010related sarcoid\u2010like reaction after starting a neoadjuvant chemoimmunotherapy regimen that included Pembrolizumab. After 4\u2009months of ongoing treatment, she started having significant nausea and vomiting. Computed tomography (CT) scans performed during hospitalization revealed multiple pathologically enlarged thoracic lymph nodes, suspicious for disease progression. Initially, the laboratory workup and cultures were unrevealing. However, esophagogastroduodenoscopy and bronchoscopy were performed, showing noncaseating granulomas in both the stomach and thoracic lymph node biopsy samples. The patient was diagnosed with a sarcoidosis\u2010like reaction to Pembrolizumab. Notably, her symptoms rapidly improved upon initiating systemic corticosteroids. Follow\u2010up CT scan showed a significant improvement in lymphadenopathy after discontinuing Pembrolizumab.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    This case emphasizes the significance of acknowledging sarcoid\u2010like reactions as possible adverse effects of Pembrolizumab. Given the rising utilization of PD\u20101 inhibitors, it becomes imperative to be mindful of such adverse events. This awareness helps avoid misdiagnosing disease progression and aids in making informed decisions about ongoing treatment with ICIs.\n                  <\/jats:p>","DOI":"10.1155\/carm\/9915002","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:23:41Z","timestamp":1747725821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pembrolizumab\u2010Associated Multiorgan Sarcoid\u2010Like Reaction: A Case Report and Review of 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