{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T10:44:45Z","timestamp":1773053085773,"version":"3.50.1"},"reference-count":77,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":67,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Critical Care Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thrombocytopenia is a common hematologic abnormality in the intensive care unit (ICU), affecting approximately 50% of patients. It is associated with increased mortality and bleeding risk. Despite its clinical significance, epidemiological studies on ICU\u2010related thrombocytopenia in Gulf Cooperation Council countries remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective observational cohort study was conducted to investigate the prevalence, risk factors, characteristics, and clinical outcomes of thrombocytopenia in the ICU. We included ICU patients admitted for \u2265\u200924\u2009h, excluding pregnant women and individuals under 18. Thrombocytopenia was defined as a platelet count &lt;\u2009150\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L after ruling out pseudothrombocytopenia. Patients were stratified by thrombocytopenia severity and followed until discharge, death, or 30\u2009days post onset. Risk factors were analyzed using multivariable modified Poisson regression models. The Naranjo probability scale and the 4Ts score were used for causal assessment of drug\u2010induced thrombocytopenia (DIT) and heparin\u2010induced thrombocytopenia (HIT). Primary outcomes included three\u2010month ICU mortality and major bleeding. Kaplan\u2013Meier with log\u2010rank tests assessed time\u2010to\u2010mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study enrolled 276 patients; 38.8% had thrombocytopenia, including 23.4% with severe thrombocytopenia. The incidence of new\u2010onset thrombocytopenia was 22.5%. DIT was suspected in 15% of cases, including five patients with potential HIT. Shock diagnosis was a significant predictor of new\u2010onset thrombocytopenia (adjusted risk ratio\u2009=\u20092.26, 95% confidence interval: 1.35\u20133.79). Thrombocytopenic patients had higher Acute Physiology and Chronic Health Evaluation (APACHE) IV scores (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and experienced more major bleeding events (16.8% vs. 8.3%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03) and higher mortality rates (27.1% vs. 5.3%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) with reduced time\u2010to\u2010mortality (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01). New\u2010onset thrombocytopenia was independently associated with major bleeding and mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Thrombocytopenia is prevalent in the ICU, correlating to disease severity, major bleeding, and mortality. The study\u2019s findings underscore the need for timely recognition and effective management of thrombocytopenia to improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/ccrp\/4492230","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:56:24Z","timestamp":1773046584000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence, Risk Factors, Characteristics, and Clinical Outcomes of Thrombocytopenia in the Intensive Care Unit: A Prospective Single\u2010Center Cohort Study"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3804-4303","authenticated-orcid":false,"given":"Zainab A.","family":"Almardod","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6537-2786","authenticated-orcid":false,"given":"Kishore G.","family":"Sam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7170-5898","authenticated-orcid":false,"given":"Eman E.","family":"Younis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.4103\/1658-5127.137147"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.5603\/AIT.2019.0011"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13699"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2243"},{"key":"e_1_2_10_5_2","first-page":"288","article-title":"Thrombocytopenia: Evaluation and Management","volume":"106","author":"Gauer R. 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