{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:59:32Z","timestamp":1790837972177,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":272,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Managing STEMI and high\u2010risk NSTEMI\u2010equivalent patients on chronic oral anticoagulation (OAC) undergoing primary PCI poses competing ischaemic and bleeding risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This single\u2010centre retrospective study enrolled 604 consecutive STEMI\/high\u2010risk NSTEMI patients undergoing primary PCI (2012\u20132023). OAC users (\n                      <jats:italic>n<\/jats:italic>\n                      = 100) were compared with propensity score\u2013matched controls (\n                      <jats:italic>n<\/jats:italic>\n                      = 203). Primary endpoints included all\u2010cause mortality, bleeding, stroke, recurrent MI and rehospitalisation over a mean 3\u2010year follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      OAC users had a higher prevalence of prior ischaemic stroke\/TIA (19% vs. 3%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and known coronary artery disease (33% vs. 20%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.015). In\u2010hospital mortality was comparable (7% vs. 5.9%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.80). Postdischarge long\u2010term mortality was significantly higher in OAC users (31% vs. 14.8%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001), as were access\u2010site haematoma (8% vs. 2%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02) and minor bleeding (7% vs. 1.5%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03). On multivariable Cox regression, OAC use was not an independent mortality predictor (HR 0.81, 95% CI 0.47\u20131.37,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.43); age, reduced ejection fraction and chronic kidney disease were the principal determinants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite higher postdischarge mortality and bleeding, OAC use was not independently associated with mortality after adjustment. Comorbidity burden drives prognosis, emphasising comprehensive risk stratification in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cdr\/1295386","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:41:05Z","timestamp":1790836865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is Oral Anticoagulation an Independent Predictor of Mortality in STEMI and High\u2010Risk NSTEMI Patients After Primary PCI? A Propensity Score\u2010Matched Retrospective Analysis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8056-3231","authenticated-orcid":false,"given":"Recep","family":"Polat","sequence":"first","affiliation":[{"name":"Department of Cardiology TC Saglik Bakanligi Dr Siyami Ersek Gogus Kalp ve Damar Cerrahisi Egitim ve Arastirma Hastanesi  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6414-3743","authenticated-orcid":false,"given":"Fuat","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Cardiology TC Saglik Bakanligi Dr Siyami Ersek Gogus Kalp ve Damar Cerrahisi Egitim ve Arastirma Hastanesi  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7075-2011","authenticated-orcid":false,"given":"Yal\u00e7\u0131n","family":"Velibey","sequence":"additional","affiliation":[{"name":"Department of Cardiology TC Saglik Bakanligi Dr Siyami Ersek Gogus Kalp ve Damar Cerrahisi Egitim ve Arastirma Hastanesi  \u0130stanbul Turkey"},{"name":"Department of Cardiology Saglik Bilimleri Universitesi  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0156-3991","authenticated-orcid":false,"given":"Osman","family":"Bolca","sequence":"additional","affiliation":[{"name":"Department of Cardiology TC Saglik Bakanligi Dr Siyami Ersek Gogus Kalp ve Damar Cerrahisi Egitim ve Arastirma Hastanesi  \u0130stanbul Turkey"},{"name":"Department of Cardiology Saglik Bilimleri Universitesi  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0948-1010","authenticated-orcid":false,"given":"G\u00f6kt\u00fcrk","family":"\u0130pek","sequence":"additional","affiliation":[{"name":"Department of Cardiology TC Saglik Bakanligi Dr Siyami Ersek Gogus Kalp ve Damar Cerrahisi Egitim ve Arastirma Hastanesi  \u0130stanbul Turkey"},{"name":"Department of Cardiology Saglik Bilimleri Universitesi  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_14_1_2","volume-title":"Cardiovascular Diseases (CVDs) Fact Sheet","author":"World Health Organization","year":"2023"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001137"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.1038"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx393"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.019"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad191"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/2048872613483019"},{"key":"e_1_2_14_9_2","first-page":"2058","article-title":"Antithrombotic Therapy in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Joint Consensus Document of the EHRA and EAPCI","volume":"41","author":"Vranckx P.","year":"2020","journal-title":"European Heart Journal"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611594"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61751-7"},{"key":"e_1_2_14_12_2","first-page":"599","article-title":"Safety and Efficacy of Oral Anticoagulants and Antiplatelet Drugs in Patients With Atrial Fibrillation and Acute Coronary Syndrome: A Meta-Analysis of Randomized Controlled Trials","volume":"5","author":"Lopes R. 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