{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:43:17Z","timestamp":1792230197706,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"vor","delay-in-days":289,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["DP2-TMU-114-A-01"],"award-info":[{"award-number":["DP2-TMU-114-A-01"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["114-2628-B-038-002-MY3"],"award-info":[{"award-number":["114-2628-B-038-002-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC113-2634-F038-001"],"award-info":[{"award-number":["NSTC113-2634-F038-001"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is standard for patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI), yet real\u2010world comparisons of ticagrelor and prasugrel remain limited. We evaluated their relative effectiveness and safety using the TriNetX Global Collaborative Network (2010\u20132024). Adult ACS patients receiving prasugrel or ticagrelor within 24\u2009h post\u2010PCI were included. The primary endpoint was a 1\u2010year composite of all\u2010cause mortality, myocardial infarction (MI), and cerebral infarction; secondary endpoints included individual components, major bleeding, and repeat revascularization. Propensity score matching balanced baseline characteristics, with subgroup and sensitivity analyses assessing robustness. Among 14,895 matched pairs (\n                    <jats:italic>n<\/jats:italic>\n                    = 29,790) from 126,273 patients, prasugrel was associated with lower risk of the composite endpoint (HR 0.641; 95% CI 0.613\u20130.671), all\u2010cause mortality (HR 0.557; 95% CI 0.487\u20130.637), and MI (HR 0.648; 95% CI 0.616\u20130.680), without increased bleeding (HR 0.945; 95% CI 0.824\u20131.084). Repeat revascularization was higher with prasugrel (HR 1.791; 95% CI 1.639\u20131.957). Effects were consistent across subgroups. In this real\u2010world setting, prasugrel demonstrated superior effectiveness over ticagrelor in reducing mortality and ischemic events without increasing the risk of bleeding, although higher rates of repeat revascularization warrant further study. These findings support prasugrel as a potentially preferred P2Y12 inhibitor in selected ACS patients undergoing PCI.\n                  <\/jats:p>","DOI":"10.1155\/cdr\/2457933","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:08:56Z","timestamp":1792228136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prasugrel Outperforms Ticagrelor in Acute Coronary Syndrome: A Real\u2010World Analysis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6669-2390","authenticated-orcid":false,"given":"Septi","family":"Melisa","sequence":"first","affiliation":[{"name":"International Ph.D. Program in Biotech and Healthcare Management College of Management Taipei Medical University  Taipei Taiwan  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cgmh.org.tw"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9525-2144","authenticated-orcid":false,"given":"Wei-Ting","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Chi Mei Hospital  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2107-612X","authenticated-orcid":false,"given":"Wei-Pin","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Health Care Administration Taipei Medical University  Taipei Taiwan  tmu.edu.tw"},{"name":"Clinical Data Center Office of Data Science Taipei Medical University  Taipei Taiwan  tmu.edu.tw"},{"name":"Clinical Big Data Research Center Taipei Medical University Hospital Taipei Medical University  Taipei Taiwan  tmuh.org.tw"},{"name":"Research Center of Data Science on Healthcare Industry College of Management Taipei Medical University  Taipei Taiwan  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