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The repeated failure of cardioprotective interventions that were effective in animal models has exposed a persistent translational gap. Human induced pluripotent stem cell\u2013derived cardiomyocytes (hiPSC\u2010CMs) and engineered cardiac platforms preserve donor\u2010specific human genetic backgrounds, provide scalable cell sources, and offer experimentally tractable systems for studying selected mechanisms of I\/R injury. Recent advances in electrical, mechanical, metabolic, and endocrine maturation, together with engineered heart tissues (EHTs), cardiac organoids, and perfused heart\u2010on\u2010a\u2010chip platforms, have improved the ability to model cardiomyocyte stress, calcium overload, mitochondrial dysfunction, oxidative injury, and multicellular crosstalk. Single\u2010cell and spatial omics, CRISPR\u2010based perturbation, and artificial intelligence (AI)\u2013assisted high\u2010content phenotyping further enable state\u2010resolved and mechanistically testable analyses of vulnerable cardiac cell populations. In this narrative review, we synthesize recent progress in hiPSC\u2010based myocardial I\/R modeling, critically evaluate the strengths and limitations of current platforms, and discuss their use in mechanism\u2010guided drug screening, cardiotoxicity assessment, and patient\u2010specific preclinical modeling. We emphasize that these systems are not yet substitutes for clinical validation or whole\u2010organ physiology. Their current value lies in providing controllable, human\u2010relevant preclinical models that can prioritize mechanisms, identify candidate interventions, and support better\u2010designed translational cardioprotection studies.<\/jats:p>","DOI":"10.1155\/cdr\/2729114","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T14:57:33Z","timestamp":1789484253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Humanized hiPSC Platforms for I\/R Injury: Advancing Toward Precision 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