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Although current therapies\u2014including angiotensin receptor\u2013neprilysin inhibitors, sodium\u2010glucose cotransporter\u20102 inhibitors, and cardiac resynchronization therapy\u2014have improved outcomes, significant limitations persist. Ginseng, a renowned traditional Chinese medicine, contains bioactive ginsenosides (e.g., Rb1, Rb3, Re, Rg1, and Rg3) that exhibit multitarget cardioprotective effects, offering a promising therapeutic strategy for HF. This review systematically elucidates the mechanisms by which ginsenosides ameliorate HF, including modulation of myocardial energy metabolism, suppression of oxidative stress and inflammation, attenuation of fibrosis, and inhibition of cardiomyocyte apoptosis. We further evaluate the synergistic efficacy of ginsenoside\u2010containing formulations (e.g., YiQiFuMai injection and Qiliqiangxin capsule) in HF management. Although clinical evidence remains limited and heterogeneous, preclinical studies robustly support ginsenosides as pleiotropic natural compounds with therapeutic potential for HF. Future research should prioritize high\u2010quality clinical trials, optimize delivery systems (e.g., nanocarriers), and explore combination therapies with conventional drugs to accelerate clinical translation.<\/jats:p>","DOI":"10.1155\/cdr\/3078311","type":"journal-article","created":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T07:05:43Z","timestamp":1777187143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrating Traditional Wisdom With Modern Science: Ginsenosides as Antiheart Failure 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