{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T21:18:34Z","timestamp":1773782314716,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":309,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24he2202019"],"award-info":[{"award-number":["JP24he2202019"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Backgrounds<\/jats:title>\n                    <jats:p>Anemia is associated with poor prognosis in heart failure patients. Erythropoiesis\u2010stimulating agents have been used for the treatment of renal anemia, but they increase the risk of thrombotic events. Hypoxia\u2010inducible factor prolyl hydroxylase inhibitors (HIF\u2010PHIs) have emerged as a new treatment for renal anemia. HIF\u2010PHIs are expected to have pleiotropic effects beyond correcting anemia. Evidence regarding the effects of HIF\u2010PHIs in cardiorenal anemia syndrome has not been established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      The present study is a single\u2010center, retrospective analysis of patients with heart failure and renal anemia who were treated with HIF\u2010PHIs or oral iron supplementation at Kyushu University Hospital (\n                      <jats:italic>n<\/jats:italic>\n                      = 39 and\n                      <jats:italic>n<\/jats:italic>\n                      = 26). Both treatments significantly raised hemoglobin levels (HIF\u2010PHIs 9.1 [8.6\u20139.6] vs. 10.3 [9.5\u201311.8],\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001; oral iron 10.1 [9.3\u201311.0] vs. 11.8 [10.6\u201313.2],\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Log\u2010transformed BNP level (logBNP) decreased in the HIF\u2010PHI\u2010treated patients but not in those treated with oral iron despite the similar improvement in hemoglobin levels (HIF\u2010PHIs 2.74 [2.28\u20132.99] vs. 2.47 [2.16\u20132.66],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005; oral iron 2.38 [1.89\u20132.66] vs. 2.37 [1.90\u20132.50],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.711). The levels of iron metabolism\u2013related parameters after treatment were comparable between the two groups.\n                      <jats:italic>\u0394<\/jats:italic>\n                      logBNP\/\n                      <jats:italic>\u0394<\/jats:italic>\n                      Hb slope was significantly steeper in the HIF\u2010PHI group than the oral iron supplementation group (\u22120.100 vs. \u22120.047,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.039), meaning that HIF\u2010PHIs further reduced BNP levels than anticipated by the increase of hemoglobin with conventional treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HIF\u2010PHIs reduce BNP levels more than anticipated by the elevation of hemoglobin levels compared to oral iron supplementation. HIF\u2010PHIs may have therapeutic benefits against heart failure beyond the correction of anemia in the heart failure patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cdr\/3143864","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T06:49:04Z","timestamp":1762498144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Hypoxia\u2010Inducible Factor Prolyl Hydroxylase Inhibitors on Relationship Between B\u2010Type Natriuretic Peptide and Hemoglobin Levels in Patients With Cardiorenal Anemia 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