{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:45:36Z","timestamp":1791805536964,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":284,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiorespiratory fitness (CRF) is a powerful predictor of cardiovascular morbidity and mortality. The cardiopulmonary exercise test (CPET) is considered a gold standard in assessing CRF. Patients with myocarditis are recommended to abstain from exercise because of the risk of sudden cardiac death (SCD). Therefore, the clinical benefit of exercise\u2010based cardiac rehabilitation (CR) has not been previously established in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study is to assess the CRF of myocarditis and the safety and effectiveness of an exercise\u2010based CR program in these populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A total of 70 consecutive patients with a diagnosis of myocarditis admitted to Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology between October 2021 and December 2024 were enrolled in the current study. CPET was performed within 3\u20136 months of hospital discharge. The exercise\u2010based CR program was performed for 3 months. The protocol included biomarker analysis, CPET, and standard\u2010of\u2010care echocardiography (including resting left ventricular ejection fraction and global longitudinal strain [GLS]). Data were collected at admission and 3 months after discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 70 patients with myocarditis were enrolled. Among them, 47 patients completed the rehabilitation program and had complete follow\u2010up assessments, including cardiopulmonary exercise testing, and were included in the final analysis. In comparison with NFM, patients with FM were more often female, and had higher levels of creatine kinase (CK), lactate dehydrogenase (LDH), urea nitrogen (UN), N\u2010terminus probrain natriuretic peptide (NT\u2010proBNP), fasting blood glucose (FBG), and white blood cell (WBC). For FM, echocardiography revealed more frequently signs of left ventricular (LV) dysfunction in the form of a reduced ejection fraction (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01), and lower GLS (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01) in contrast to NFM. CPET results showed that FM patients had markedly lower exercise capacity, impaired ventilatory efficiency, and pulmonary function (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). After the 3\u2010month exercise\u2010based CR program, both groups demonstrated significant improvements in peak VO\n                      <jats:sub>2<\/jats:sub>\n                      , peak workload, and MVV. However, no significant between\u2010group differences were observed in the magnitude of improvement in CRF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CRF was substantially impaired in patients recovering from myocarditis, particularly among those with fulminant presentations. Participation in a structured 3\u2010month exercise\u2010based CR program was feasible and was associated with favorable changes in exercise capacity and cardiopulmonary performance.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Chinese Clinical Trial Registry: ChiCTR2400088436\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cdr\/3611934","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:56:32Z","timestamp":1791802592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiopulmonary Fitness and Exercise\u2010Based Cardiac Rehabilitation in Patients With Myocarditis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0356-0906","authenticated-orcid":false,"given":"Si-Si","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital National Clinical Research Center for Cardiovascular Diseases Capital Medical University  Beijing China  ccmu.edu.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1015-3476","authenticated-orcid":false,"given":"Lu-Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Tongji Medical College Tongji Hospital Huazhong University of Science and Technology  Wuhan China  hust.edu.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9109-5460","authenticated-orcid":false,"given":"Hou-Juan","family":"Zuo","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Tongji Medical College Tongji Hospital Huazhong University of Science and Technology  Wuhan China  hust.edu.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3074-6298","authenticated-orcid":false,"given":"Wan-Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Tongji Medical College Tongji Hospital Huazhong University of Science and Technology  Wuhan China  hust.edu.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht210"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-023-2421-0"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000664"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.058869"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487320905719"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000239"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2017.03.022"},{"key":"e_1_2_12_8_2","first-page":"300","article-title":"Statement on Cardiopulmonary Exercise Testing in Chronic Heart Failure due to Left Ventricular Dysfunction: Recommendations for Performance and Interpretation Part II: How to Perform Cardiopulmonary Exercise Testing in Chronic Heart Failure","volume":"13","author":"Piepoli M. 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