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Shenfu injection, a traditional Chinese medicine formulation, has shown cardioprotective effects in preclinical studies. This trial is aimed at investigating whether Shenfu injection as an adjunctive therapy to standard treatment could reduce arrhythmias and improve clinical outcomes in patients with STEMI undergoing percutaneous coronary intervention (PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A single\u2010center, prospective, randomized, controlled trial was conducted at Shanghai Ninth People\u2032s Hospital among 245 patients with STEMI undergoing PCI. Participants were randomized to receive either standard therapy plus Shenfu injection (50\u2009mL, administered intravenously twice daily for five consecutive days) (\n                      <jats:italic>n<\/jats:italic>\n                      = 123) or standard therapy alone (\n                      <jats:italic>n<\/jats:italic>\n                      = 122). The primary endpoint was the incidence of in\u2010hospital arrhythmias. Secondary endpoints included major adverse cardiac events (MACEs) during the 12\u2010month follow\u2010up period and cardiac magnetic resonance imaging parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 245 patients underwent randomization (123 assigned to Shenfu injection group and 122 assigned to control group). During hospitalization, patients assigned to Shenfu injection had a significantly lower incidence of arrhythmias compared with the control group (24.4% vs. 38.5%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.017), with the most pronounced effect on frequent ventricular premature contractions (7.3% vs. 15.5%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.042). After adjustment for key baseline covariates including age, coronary artery disease extent, myocardial injury markers (CK\u2010MB max and TNI max), left ventricular ejection fraction, B\u2010type natriuretic peptide, door\u2010to\u2010balloon time, hypertension, and diabetes mellitus, Shenfu injection remained independently associated with reduced risk of in\u2010hospital arrhythmias (adjusted OR 0.454, 95% CI: 0.249\u20130.827,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.010). Cardiac magnetic resonance imaging performed in 174 patients revealed significantly smaller infarct size (16.1 \u00b1 9.1 vs. 20.8 \u00b1 13.1\u2009g,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007) and lower incidence of microvascular obstruction (45.0% vs. 65.0%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.008) in the Shenfu group, with both parameters showing significant positive correlations with arrhythmia occurrence. During the 12\u2010month follow\u2010up, patients receiving Shenfu injection had a higher event\u2010free rate from MACEs compared with the control group (12\u2010month Kaplan\u2010Meier event\u2010free rate estimates, 84.6% vs. 73.0%, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.028).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment with Shenfu injection as an adjunctive therapy to standard treatment in patients with STEMI undergoing PCI significantly reduced in\u2010hospital arrhythmias, infarct size, microvascular obstruction, and major adverse cardiac events during a 12\u2010month follow\u2010up period. The independent effect on arrhythmias after comprehensive statistical adjustment and the demonstrated correlation between reduced myocardial damage and arrhythmia prevention suggest the potential therapeutic value of Shenfu injection in improving both short\u2010term and long\u2010term outcomes in STEMI patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Registry Identifier: ChiCTR2200066918<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cdr\/4097327","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T07:23:22Z","timestamp":1764573802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Preventive Effect of Shenfu Injection on Arrhythmia After Percutaneous Coronary Intervention in Patients With ST\u2010Segment Elevation Myocardial Infarction: A Prospective Randomized Controlled 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