{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:39:48Z","timestamp":1792492788191,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":292,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Heart\u2010type fatty acid\u2010binding protein (H\u2010FABP) is rapidly released following myocardial injury, but its prognostic significance in acute coronary syndrome (ACS) remains uncertain. We evaluated the association between elevated H\u2010FABP and adverse clinical outcomes in confirmed or suspected ACS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase, CENTRAL, Web of Science and Scopus were searched from inception to 30 August 2026 without date restriction. Studies assessing diagnostic and\/or prognostic relevance of circulating H\u2010FABP in adults with confirmed or suspected ACS were eligible. Prognostic outcomes included all\u2010cause mortality, major adverse cardiovascular events (MACE), heart failure (HF)\u2013related hospitalisation and recurrent myocardial infarction (MI). Risk of bias was assessed using QUIPS. Crude odds ratios (ORs) from extractable 2 \u00d7 2 event data were pooled using inverse\u2010variance random\u2010effects models with restricted maximum\u2010likelihood estimation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve studies were included, with five contributing to meta\u2010analysis. Elevated H\u2010FABP was associated with higher odds of all\u2010cause mortality (OR 5.68; 95% CI 3.98\u20138.09;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 30\n                      <jats:italic>%<\/jats:italic>\n                      ), MACE (OR 4.56; 95% CI 1.97\u201310.55;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 47\n                      <jats:italic>%<\/jats:italic>\n                      ), HF\u2010related hospitalisation (OR 4.29; 95% CI 2.94\u20136.26;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0\n                      <jats:italic>%<\/jats:italic>\n                      ) and recurrent MI (OR 1.65; 95% CI 1.15\u20132.37;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0\n                      <jats:italic>%<\/jats:italic>\n                      ). Pooled estimates were unadjusted; seven studies were synthesised narratively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated H\u2010FABP is associated with adverse outcomes in ACS, but current evidence does not establish independent prognostic value. Further prospective studies should determine whether H\u2010FABP adds predictive value beyond established clinical and biochemical risk markers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cdr\/4836688","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:58:30Z","timestamp":1792490310000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Heart\u2010Type Fatty Acid\u2010Binding Protein in Patients With Acute Coronary Syndrome: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8257-1260","authenticated-orcid":false,"given":"Ahmed","family":"Elmewafy","sequence":"first","affiliation":[{"name":"School of Medicine University of Sheffield  Sheffield UK  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Ireland  rcsi.ie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Farooq","sequence":"additional","affiliation":[{"name":"Royal Blackburn Teaching Hospital East Lancashire Hospitals NHS Trust  Blackburn UK  nhs.uk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Gamal","sequence":"additional","affiliation":[{"name":"School of Medicine St. George\u2032s University  St. George\u2032s Grenada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4374-7476","authenticated-orcid":false,"given":"Ibrahim","family":"Antoun","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Sciences Clinical Science Wing University of Leicester Glenfield Hospital  Leicester UK  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