{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:49:18Z","timestamp":1781196558054,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This network meta\u2010analysis (NMA) evaluated four novel proprotein convertase subtilisin\/kexin type 9 (PCSK9) monoclonal antibodies for hypercholesterolemia management, comparing their lipid\u2010lowering efficacy and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We systematically identified randomized controlled trials employing the frequentist NMA method to assess reductions in low\u2010density lipoprotein cholesterol (LDL\u2010C), apolipoprotein B (ApoB), and lipoprotein (a) (Lp[a]), alongside treatment\u2010emergent adverse events (TEAEs) and serious TEAEs.\n                      <jats:italic>P<\/jats:italic>\n                      \u2010scores ranked therapeutic hierarchies, with meta\u2010regression and subgroup analyses exploring heterogeneity. Trial sequential analysis determined the adequacy of cumulative evidence. Confidence in the network meta\u2010analysis approach was used to evaluate the confidence in the findings from NMA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of eight trials with 3,975 Chinese patients were included. Ongericimab 150\u2009mg every 2 weeks (Q2W) ranked first in all efficacy outcomes, demonstrating pronounced effects in LDL\u2010C, ApoB, and Lp(a) reduction versus placebo, with mean differences of \u221274.21% (95% confidence interval [CI]: \u221279.69% to \u221268.73%), \u221264.36% (95% CI: \u221268.58% to \u221260.13%), and \u221250.93% (95% CI: \u221256.24% to \u221245.61%), respectively. All interventions exhibited safety profiles comparable with placebo, with no significant differences in TEAEs or serious TEAEs incidence. The analyses suggested that a portion of the evidence base was robust and reliable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings positioned ongericimab 150\u2009mg Q2W as a clinically optimal PCSK9 inhibitor with robust lipid\u2010lowering capacity. The results highlight the potential of next\u2010generation PCSK9 monoclonal antibodies, particularly in East Asian populations, while underscoring the need for large\u2010scale multinational trials to validate ethnic\u2010specific responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cdr\/6345873","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:47:26Z","timestamp":1769266046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Efficacy and Safety of Four Novel PCSK9 Monoclonal Antibodies in Patients With Hypercholesterolemia: A Systematic Review With Network Meta\u2010Analysis and Trial Sequential Analysis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6550-5059","authenticated-orcid":false,"given":"Sihua","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7526-7467","authenticated-orcid":false,"given":"Chenyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1252-9459","authenticated-orcid":false,"given":"Duncong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.3.311"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000624"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz455"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwae281"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2024-324650"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.11.007"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.11.286"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-7-11"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1099800412436967"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.10.039"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12981"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.069556"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2023.03.004"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173114"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0107-8"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2021.03.042"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvad019"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v106.i02"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1167"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1316"},{"key":"e_1_2_13_23_2","unstructured":"HigginsJ. 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