{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:43:43Z","timestamp":1792500223965,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":292,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Propofol (PPF) alleviates myocardial ischemia\/reperfusion injury (MIRI), yet no existing studies have clarified the function of microRNA\u2010511\u20103p (miR\u2010511\u20103p) in cardiac injury or its link to PPF\u2032s cardioprotection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      This study clarified how the miR\u2010511\u20103p\/ATPase sarcoplasmic\/endoplasmic reticulum Ca\n                      <jats:sup>2+<\/jats:sup>\n                      transporting 2 (ATP2A2) signaling cascade mediated PPF\u2010induced relief against hypoxia\/reoxygenation (H\/R) cardiac damage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>H\/R damage models were established in H9c2 cells. Cell viability was measured via the CCK\u20108 assay, and flow cytometry was used to quantify the proportion of apoptotic cells. Cellular reactive oxygen species (ROS) levels were assessed using the DCFH\u2010DA fluorescent staining method. ELISA and colorimetric tests were combined to measure cardiac injury markers, inflammatory mediators, and oxidative stress\u2010related molecules. RT\u2010qPCR was applied to test the expression levels of miR\u2010511\u20103p and ATP2A2. Dual\u2010luciferase reporter assays were carried out to confirm the direct binding interaction between the two molecules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PPF markedly boosted the viability and restrained apoptosis of H9c2 cells subjected to H\/R treatment. It also reduced the release of cardiac injury markers and eased excessive oxidative stress and inflammatory responses. H\/R exposure raised miR\u2010511\u20103p abundance, an alteration that PPF treatment could reverse. Forced miR\u2010511\u20103p expression partially abolished the cardioprotective benefits brought by PPF. ATP2A2 was verified as a direct target of miR\u2010511\u20103p, whose expression was suppressed by this miRNA. Upregulating ATP2A2 counteracted cell damage triggered by miR\u2010511\u20103p overexpression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PPF might mitigate H\/R\u2010triggered cardiomyocyte damage, possibly through inhibiting miR\u2010511\u20103p and increasing its target ATP2A2, and this molecular axis may offer a tentative therapeutic reference for MIRI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cdr\/7021184","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:56:27Z","timestamp":1792497387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The miR\u2010511\u20103p\/ATP2A2 Axis Is Required for Propofol\u2010Mediated Cardioprotection Against Hypoxia\/Reoxygenation Injury"],"prefix":"10.1155","volume":"2026","author":[{"given":"Yan","family":"Sun","sequence":"first","affiliation":[{"name":"West China School of Medicine Sichuan University  Chengdu China  scu.edu.cn"},{"name":"Department of Anesthesiology Sichuan University Affiliated Chengdu Second People\u2032s Hospital  Chengdu China"},{"name":"Department of Anesthesiology Chengdu Second People\u2032s Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"West China School of Medicine Sichuan University  Chengdu China  scu.edu.cn"},{"name":"Department of Anesthesiology Sichuan University Affiliated Chengdu Second People\u2032s Hospital  Chengdu China"},{"name":"Department of Anesthesiology Chengdu Second People\u2032s Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhu","sequence":"additional","affiliation":[{"name":"West China School 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