{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T09:19:53Z","timestamp":1775035193445,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":89,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2024AH051281"],"award-info":[{"award-number":["2024AH051281"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The present study is aimed at investigating the effects of statins on all\u2010cause and cardiovascular mortalities in individuals with cardiovascular\u2013kidney\u2013metabolic syndrome (CKMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data from the National Health and Nutrition Examination Survey (NHANES) 1999\u20132018, we identified individuals with CKMS and categorized them into statin\u2010treated and untreated groups based on statin exposure. A propensity score matching (PSM) model was applied to balance baseline characteristics between the two groups. All\u2010cause and cardiovascular mortalities were then assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 19087 individuals with CKMS were enrolled, yielding 4762 matched individuals. Compared with the statin\u2010untreated group, statin therapy was associated with significant mortality benefits in CKMS individuals, demonstrating a 27% reduction in all\u2010cause mortality (HR 0.73, 95% CI 0.65\u20130.82) and a 26% decrease in cardiovascular mortality (HR 0.74, 95% CI 0.61\u20130.90). Stratified analyses by CKMS stage showed no significant interaction between disease stage and statin use for either all\u2010cause (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009for\u2009interaction = 0.81) or cardiovascular mortality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009for\u2009interaction = 0.13), although statistically significant inverse associations were primarily observed in individuals with advanced CKMS stages. Analyses by statin type indicated that atorvastatin and simvastatin were associated with reduced risks of both all\u2010cause and cardiovascular mortalities, whereas rosuvastatin was associated with a reduced risk of all\u2010cause mortality only. Exploratory subgroup analyses suggested that the associations were more evident among individuals with intermediate levels of total cholesterol (200\u2013240\u2009mg\/dL) and LDL cholesterol (130\u2013160\u2009mg\/dL).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this nationally representative cohort, statin use was associated with lower risks of all\u2010cause and cardiovascular mortalities among individuals with CKMS. These findings warrant confirmation in prospective studies with larger sample sizes to further clarify potential heterogeneity across statin type, disease stages, and different lipid profiles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cdr\/7480081","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:21:52Z","timestamp":1775024512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Statin Use on Mortality in Individuals With Cardiovascular\u2013Kidney\u2013Metabolic Syndrome: A Retrospective Propensity Score\u2010Matched Cohort 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