{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:05:01Z","timestamp":1789974301804,"version":"4.0.1"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":262,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305092"],"award-info":[{"award-number":["82305092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574922"],"award-info":[{"award-number":["82574922"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study is aimed at evaluating the effects of Zhenwu Decoction (ZWD) on cardiac dysfunction, water\u2010retention\u2013related phenotypes, and brain and kidney injury in rats with doxorubicin\u2010induced chronic heart failure (CHF), and at examining whether these effects were accompanied by changes in AVP, V2R, PKA\u2010C\n                      <jats:italic>\u03b1<\/jats:italic>\n                      , and AQP2\u2010related markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Rats that met the prespecified CHF criteria after doxorubicin administration were rerandomized to the model, ZWD\u2010L, ZWD\u2010M, ZWD\u2010H, or tolvaptan groups and treated once daily for 14 consecutive days. Cardiac function, biochemical and water balance\u2013related outcomes, histopathology, brain AVP, and renal V2R, PKA\u2010C\n                      <jats:italic>\u03b1<\/jats:italic>\n                      , and AQP2 expression were assessed. The animal was the experimental unit, and the number analyzed is reported for each outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the control group, model rats showed impaired cardiac function; increased ascites and tissue water retention; reduced 24\u2010h urine output; histological injury in the heart, brain, and kidney; and altered AVP, V2R, PKA\u2010C\n                      <jats:italic>\u03b1<\/jats:italic>\n                      , and AQP2\u2010related markers. ZWD treatment was associated with improvement in these measured outcomes, with the magnitude and statistical support varying across doses. Tolvaptan produced the expected aquaretic reference response. Adjusted\n                      <jats:italic>p<\/jats:italic>\n                      values and the number of animals analyzed are reported for each outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In this doxorubicin\u2010induced CHF model, ZWD improved cardiac function and water\u2010retention\u2013related phenotypes and was accompanied by changes in AVP, V2R, PKA\u2010C\n                      <jats:italic>\u03b1<\/jats:italic>\n                      , and AQP2\u2010related markers. These data support an association but do not establish pathway mediation, direct target engagement, or heart\u2013brain\u2013kidney crosstalk.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cdr\/8444915","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:55:02Z","timestamp":1789973702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zhenwu Decoction Attenuates Water\u2010Retention\u2013Related Phenotypes and Multiorgan Injury in Rats With Doxorubicin\u2010Induced Chronic Heart 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