{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T11:53:19Z","timestamp":1781610799198,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":166,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72204073"],"award-info":[{"award-number":["72204073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Proprotein convertase subtilisin\/kexin type 9 (PCSK9) inhibitors demonstrate significant lipid\u2010lowering effects, but the widespread use of anti\u2010PCSK9 monoclonal antibodies remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study is aimed at understanding patients\u2032 real\u2010world experiences with anti\u2010PCSK9 monoclonal antibodies from a subjective perspective and identifying key factors influencing medication adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A qualitative research methodology was employed, involving face\u2010to\u2010face semistructured in\u2010depth interviews with 24 individuals who had previously used anti\u2010PCSK9 monoclonal antibodies. The interviews were guided by a thematic framework approach and recorded in their entirety. Posttranscription, Colaizzi\u2032s phenomenological analysis method was utilized to systematically collect and interpret patient\u2010reported subjective experiences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among those continuing treatment, the most common motivating factors were the anti\u2010PCSK9 monoclonal antibodies\u2032 favorable efficacy and fewer adverse reactions. Among those discontinuing treatment, the primary reasons for stopping were high medication costs (62.5%), insufficient recognition of the necessity for continued use (62.5%), and unwillingness to use injection administration (68.75%). The underlying determinants of patients\u2032 behavioral patterns can be elucidated and mitigated by applying the health belief model and the theory of planned behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Research findings indicate that patients\u2032 willingness to use medication is primarily influenced by three factors: perceived good efficacy, health awareness, and fear of needles and economic burden. We are aimed at enhancing long\u2010term clinical benefits for patients and improving treatment adherence, establishing education about drug efficacy and necessity, promoting innovation of nasal spray or long\u2010acting implant formulations, and achieving precise medical insurance coverage for high\u2010risk populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ChiCTR registration number: ChiCTR2500101339<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cdr\/8814045","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T11:13:42Z","timestamp":1781608422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Other Side of Medication: A Patient Interview Study on Anti\u2010PCSK9 Monoclonal 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