{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T21:19:41Z","timestamp":1773782381173,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":295,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100016983","name":"Shanghai Clinical Research Center","doi-asserted-by":"publisher","award":["19MC1910300"],"award-info":[{"award-number":["19MC1910300"]}],"id":[{"id":"10.13039\/501100016983","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated the impact of pathological differences between aortic stenosis (AS) and aortic regurgitation (AR) on hemodynamic outcomes following transcatheter aortic valve replacement (TAVR), with a focus on the performance of self\u2010expanding valves relative to annular anatomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this single\u2010center, retrospective study, patients undergoing TAVR for AS or AR were stratified by annulus area into smaller (&lt;\u2009430\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      ) and larger (\u2265\u2009430\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      ) subgroups. Valve sizing was based on annular dimensions (\u2265\u200927\u2009mm for AR\/smaller annulus; &lt;\u200927\u2009mm for AS subgroups). Hemodynamic parameters (aortic valve area [AVA], pressure gradients, and velocity) and prosthesis characteristics (sheath size and compression ratio) were evaluated pre\u2010 and postoperatively, with 1\u2010year follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The AR group required larger sheaths (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.006) and demonstrated superior hemodynamics compared to the AS group: larger postoperative AVA (3.0 \u00b1 0.4\u2009vs. 2.2 \u00b1 0.5\u2009 and 2.1 \u00b1 0.6\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      in larger and smaller annuli, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001); lower maximum (9.7 \u00b1 4.3 vs. 15.8 \u00b1 9.2 and 18.8 \u00b1 10.8\u2009mmHg in larger and smaller annuli, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and mean gradients (7.8 \u00b1 4.4\u2009mmHg vs. others,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001); and reduced aortic velocity (1.60 \u00b1 0.43 vs. others,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.038). Smaller annuli exhibited higher prosthesis compression (0.88 \u00b1 0.04 vs. 0.84 \u00b1 0.04 in AR and 0.8 \u00b1 0.06 in larger annulus,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), with 20% (\n                      <jats:italic>n<\/jats:italic>\n                      = 8) developing elevated transvalvular gradients (&gt;\u200920\u2009mmHg) at follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>One\u2010year outcomes revealed distinct hemodynamic profiles post\u2010TAVR between AR and AS groups based on annular size. Patients with AR exhibited more favorable valve performance, supporting TAVR in younger, low\u2010risk patients with AR who have suitable annular anatomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cdr\/8821435","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:33:18Z","timestamp":1761219198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemodynamic Variability in Aortic Stenosis and Regurgitation During Transcatheter Aortic Valve Replacement With Self\u2010Expanding Valves"],"prefix":"10.1155","volume":"2025","author":[{"given":"Mingfei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shasha","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9643-5416","authenticated-orcid":false,"given":"Xiaochun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0530-261X","authenticated-orcid":false,"given":"Wenzhi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9814-3630","authenticated-orcid":false,"given":"Daxin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9360-7332","authenticated-orcid":false,"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.6"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317979"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-23-00840"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)01064-9"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.08.049"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.006"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.05.018"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)90948-4"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960170208"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312573"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.097"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.09.039"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.2478\/jtim-2023-0140"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2023.09.012"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2024.05.015"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312514"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.21037\/acs-2024-aae-26"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.06.001"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2023.11.023"}],"container-title":["Cardiovascular 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