{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:54:23Z","timestamp":1791269663584,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":277,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients undergoing transcatheter aortic valve implantation (TAVI) remain at risk of adverse cardiovascular and renal outcomes despite procedural advancements. Sodium\u2013glucose cotransporter 2 (SGLT2) inhibitors have demonstrated cardiovascular and renal benefits across various patient populations; however, their role in patients undergoing TAVI remains unclear. This study is aimed at evaluating the association between SGLT2 inhibitor use and clinical outcomes in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic review and meta\u2010analysis comparing SGLT2 inhibitors versus non\u2010SGLT2 inhibitors or standard care in patients undergoing TAVI. Major databases were searched through March 2026, with Embase updated through June 2026. Pooled analyses were performed using random\u2010effects models to calculate risk ratios (RRs) and mean differences (MDs) with 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five studies involving 6111 patients (SGLT2 inhibitors:\n                      <jats:italic>n<\/jats:italic>\n                      = 2933; control:\n                      <jats:italic>n<\/jats:italic>\n                      = 3178) were included. In primary random\u2010effects models, SGLT2 inhibitors were associated with lower all\u2010cause mortality (RR 0.68, 95% CI 0.48\u20130.97,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03), heart failure (HF) hospitalization (RR 0.62, 95% CI 0.42\u20130.90,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01), and major adverse cardiovascular events (RR 0.68, 95% CI 0.48\u20130.96,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03). However, in REML\/Hartung\u2013Knapp sensitivity analyses, CIs crossed the null for all\u2010cause mortality, HF hospitalization, MACE, and pooled hazard ratios. Mortality benefits were absent at 6 and 12 months and in the randomized trial but persisted in low left ventricular ejection fraction (RR 0.56, 95% CI 0.35\u20130.89,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01). No significant differences occurred in acute kidney injury, urinary tract infections, or echocardiographic parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SGLT2 inhibitor use was associated with lower all\u2010cause mortality and HF hospitalization after TAVI, but the evidence is limited by observational designs, heterogeneity, and low certainty for several outcomes. Further randomized trials are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cdr\/8933859","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:38:05Z","timestamp":1791268685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Sodium\u2013Glucose Cotransporter 2 Inhibitor Use With Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation: A Systematic Review and GRADE\u2010Assessed Meta\u2010Analysis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4207-4934","authenticated-orcid":false,"given":"Ahmed Adel","family":"Mohamed","sequence":"first","affiliation":[{"name":"Faculty of Medicine Zagazig University  Zagazig Egypt  zu.edu.eg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3354-3531","authenticated-orcid":false,"given":"Batool Husain","family":"Husain","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Cairo University  Cairo Egypt  cu.edu.eg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammam Khaled","family":"Dali","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Zagazig University  Zagazig Egypt  zu.edu.eg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa Elsayed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Zagazig University  Zagazig Egypt  zu.edu.eg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4484-1278","authenticated-orcid":false,"given":"Ghaida","family":"Al Shawawreh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Mansoura University  Al Mansurah Egypt  mans.edu.eg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2986-4155","authenticated-orcid":false,"given":"Ali Samir","family":"Galal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Assiut University  Assiut Egypt  aun.edu.eg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Abdelwahab","family":"Moussa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Zagazig University  Zagazig Egypt  zu.edu.eg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah M.","family":"Hibysh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine New Ismaila National University  Ismaila Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8356-5868","authenticated-orcid":false,"given":"Abdalrahman Salah","family":"Shehata","sequence":"additional","affiliation":[{"name":"Faculty of Medicine South Valley University  Qena Egypt  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