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However, its specific impact on diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of the study is to evaluate carvedilol\u2032s efficacy in preventing concentric cardiac remodelling in at\u2010risk individuals and modulating it in patients with HFpEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In adherence to PRISMA guidelines, we searched PubMed and ScienceDirect up to March 2024 using terms related to carvedilol and HFpEF. We included randomised controlled trials and prospective cohort studies published in English. Outcomes include changes in natriuretic peptides and echocardiography parameters of diastolic function. Exclusion criteria encompassed non\u2010English studies, nonhuman studies and studies not using carvedilol or exclusively involving HFrEF patients. Risk of bias was assessed using the revised Cochrane tool and Newcastle\u2013Ottawa Scale. Data synthesis was performed using a random\u2010effects meta\u2010analysis with sensitivity analyses and a leave\u2010one\u2010out procedure to explore heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighteen studies involving 2233 participants were included. Various populations were included: those with HFpEF or undergoing cardiotoxic chemotherapy. Meta\u2010analysis did not reveal significant effects of carvedilol on echocardiography parameters such as E\/A ratio (mean difference 0.04, 95% CI \u22120.01 to 0.08), E\/e\u2009\n                      <jats:sup>\u2032<\/jats:sup>\n                      ratio (mean difference \u22120.50, 95% CI \u22121.39 to 0.39) and LVMI (mean difference 0.21, 95% CI \u22123.13 to 3.55), with substantial heterogeneity observed in LVEF, LVMI and BNP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Carvedilol does not significantly impact diastolic dysfunction across various populations. However, the diversity of study populations and outcomes contributes to the heterogeneity of results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cdr\/9108324","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T01:57:07Z","timestamp":1761703027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is Carvedilol Effective in Preventing and Modulating Concentric Cardiac Remodelling? 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