{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T21:17:24Z","timestamp":1773782244044,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T00:00:00Z","timestamp":1755302400000},"content-version":"vor","delay-in-days":227,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>This study explores the predictive utility of brain natriuretic peptide (BNP) levels in assessing outcomes for patients with chronic left heart failure (LHF). A cohort of 59 patients diagnosed with chronic LHF was compared to 59 healthy controls. BNP levels, alongside other cardiac function parameters, such as left ventricular ejection fraction (LVEF) and left ventricular end\u2010systolic dimension (LVESD), were evaluated. Results revealed that BNP levels were positively correlated with worsening cardiac function and negatively correlated with LVEF. In individuals with obesity or Type 2 diabetes mellitus, BNP levels were unexpectedly lower, whereas patients with chronic kidney disease or atrial fibrillation exhibited elevated BNP levels. A BNP cut\u2010off value of 98.9 was identified, demonstrating high diagnostic sensitivity (91.53%), specificity (83.05%), and accuracy (88.14%). The area under the ROC curve (AUC) indicated strong diagnostic performance for BNP in predicting adverse cardiovascular events. The findings underscore BNP\u2019s value not only as a biomarker for diagnosing LHF but also in prognostication and tailoring patient\u2010specific interventions. Future studies should validate these findings across diverse populations to enhance clinical application.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    Chinese Clinical Trial Registry identifier: ChiCTR2500101966\n                  <\/jats:p>","DOI":"10.1155\/cdr\/9353377","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T08:03:57Z","timestamp":1755331437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Application Value of Brain Natriuretic Peptide in the Prognostic Evaluation of Patients With Chronic Left Heart 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