{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:51:21Z","timestamp":1791553881361,"version":"4.3.4"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":281,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Diabetic cardiomyopathy (DCM) lacks targeted therapies. This study investigated naringenin (NAR), a citrus flavonoid, in a streptozotocin (STZ)\u2010induced diabetic rat model with cardiac complications, focusing on SIRT1\u2010mediated mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Rats (\n                      <jats:italic>n<\/jats:italic>\n                      = 8\/group) included control, NAR, DCM, DCM\u2009+\u2009NAR, and DCM\u2009+\u2009NAR\u2009+\u2009EX\u2010527 (SIRT1 inhibitor). After 8 weeks, metabolic profiles, cardiac function, histopathology, oxidative stress (Nuclear Factor Erythroid\u2013Related Factor 2 [Nrf2], MDA, SOD, and GSH), inflammation (nuclear factor kappa B [NF\u2010\n                      <jats:italic>\u03ba<\/jats:italic>\n                      B], TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      , and IL\u20106), apoptosis (Bax\/Bcl\u20102 and Caspase\u20103), fibrosis (transforming growth factor beta [TGF\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ] and Smad2), and SIRT1 signaling were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      NAR exhibited hypoglycemic effects, stimulated the release of insulin, and enhanced the lipid profile, thus maintaining the structural integrity of cardiomyocytes and preventing an increase in heart weight, while also restoring the histomorphology in DCM rats. Moreover, NAR influenced both systolic and diastolic blood pressure; reduced serum levels of CK\u2010MB, BNP, and troponin T; downregulated the activity of TGF\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      , Smad2, and Caspase\u20103; and decreased the Bax\/Bcl\u20102 ratio. Crucially, NAR upregulated SIRT1 and modulated the levels of Nrf2, NF\u2010\n                      <jats:italic>\u03ba<\/jats:italic>\n                      B, Smad2, and Forkhead Box Protein O1 (FOXO1) in the cardiac tissues of the DCM group. These findings were associated with a significant reduction in oxidative stress and inflammation, alongside diminished NF\u2010\n                      <jats:italic>\u03ba<\/jats:italic>\n                      B activity, while promoting Nrf2 activity and Bcl\u20102. Importantly, the effects of NAR were counteracted by EX\u2010527.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NAR protects against DCM primarily through SIRT1 activation, integrating hypoglycemic, antioxidant, anti\u2010inflammatory, antifibrotic, and antiapoptotic actions. SIRT1 represents a promising target for flavonoid\u2010based DCM therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cdr\/9581618","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:12:21Z","timestamp":1791551541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Naringenin Attenuates Diabetic Cardiac Injury via SIRT1 Activation in Streptozotocin\u2010Induced Rats"],"prefix":"10.1155","volume":"2026","author":[{"given":"Baolan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology The Fourth People\u2032s Hospital of Jinan Affiliated to Shandong Second Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Fourth People\u2032s Hospital of Jinan Affiliated to Shandong Second Medical 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