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Patients with Child A cirrhosis have a low risk of treatment failure and mortality. The present study was designed to investigate the association between antibiotics and Child\u2013Pugh A patients with AVB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective analysis was conducted on Child\u2013Pugh class A cirrhotic patients presenting with AVB at West China Hospital between January 2016 and November 2022. The outcome indicators evaluated in this study include the rate of treatment failure within five days, mortality within 6 weeks, incidence of nosocomial infections, and 1\u2010year cumulative mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study ultimately enrolled 237 patients. The day of patients\u2019 admission was defined as Day 0. A total of 117 patients received prophylactic use of antibiotics on Days 0\u20131 (Group A), and 120 patients did not receive antibiotics on Days 0\u20131 (Group B). Baseline characteristics were well\u2010balanced between the two groups. The 5\u2010day treatment failure was 8.5% in Group A and 6.7% in Group B (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.63). The 6\u2010week mortality was 1.71% in Group A and 0% in Group B (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.24). The incidence of nosocomial infection (5.98% vs. 6.67%,\n                      <jats:italic>p<\/jats:italic>\n                      = 1.00) and 1\u2010year cumulative mortality (4.81% vs. 1.89%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.40) was comparable between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The antibiotics\u2019 prophylactic use was not associated with 5\u2010day treatment failure or 6\u2010week mortality. Prophylactic use of antibiotics may not be routinely necessary in patients with Child A cirrhosis and AVB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cjgh\/2030627","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:08:41Z","timestamp":1776074921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prophylactic Antibiotic Use and Clinical Outcomes in Patients With Child\u2013Pugh A Cirrhosis and Acute Variceal Bleeding: A Retrospective Cohort 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