{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:57:20Z","timestamp":1774400240408,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":99,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>CKD\u2010495 is a newly developed drug extracted from Cinnamomum cassia Presl. This phase II study assessed the clinical benefits of CKD\u2010495 in the treatment of acute and chronic gastritis. This study randomly assigned 250 patients with endoscopically\u2010proven gastric mucosal erosion to five groups. The groups received either 75\u2009mg or 150\u2009mg of CKD\u2010495, 100\u2009mg of rebamipide, 60\u2009mg of Artemisiae argyi folium 95% ethanol ext. (20\u2009\u27f6\u20091) (Stillen; Dong\u2010A ST Co., Ltd., Seoul, Korea), or placebo for 2\u2009weeks, respectively. The primary endpoint was the erosion improvement rate, and the secondary endpoints were erosion cure rates, improvement rates of gastrointestinal symptoms, edema, redness, and hemorrhage. Drug\u2010related adverse events were evaluated. The endoscopic erosion improvement rate was significantly higher in the 75\u2009mg CKD\u2010495 group than in the other groups in both the full analysis set (73% vs. 41%, 45%, 52%, 48% for the 75\u2009mg CKD\u2010495, 150\u2009mg CKD\u2010495, placebo, 60\u2009mg Stillen, and 100\u2009mg rebamipide groups, respectively) and the per\u2010protocol set (PPS) (75% vs. 37%, 45%, 51%, 50%). The cure rate of gastric erosion was significantly higher in the 75\u2009mg CKD\u2010495 group than in the other groups. The improvement rates of hemorrhage erosion were significantly higher in the 150\u2010mg CKD\u2010495 group. No significant differences were observed in the safety profiles. No serious adverse events or drug reactions were observed. These results demonstrate that 75\u2009mg of CKD\u2010495 has excellent efficacy for the treatment of endoscopic and symptomatic improvements for acute and chronic gastritis.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    ClinicalTrials.gov identifier: NCT03437785\n                  <\/jats:p>","DOI":"10.1155\/cjgh\/2702089","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:44:06Z","timestamp":1744332246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Phase 2, Multi\u2010Center, Randomized, Double\u2010Blind, Parallel\u2010Group Trial to Evaluate the Efficacy and Safety of CKD\u2010495 in Patients With Acute and Chronic Gastritis"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6409-6895","authenticated-orcid":false,"given":"Su Hyun","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6025-530X","authenticated-orcid":false,"given":"Oh Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Chan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Sik","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Jae","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moo In","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geun Am","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunsoo","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Kook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Nyeun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suck-Chei","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam Ryong","family":"Jee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Sun","family":"Rew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Teik","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Kwang","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwang Ho","family":"Baik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin Jung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5107(95)70043-9"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0300-5089(21)00617-9"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1987.tb09342.x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.030"},{"key":"e_1_2_9_5_2","first-page":"25","article-title":"Update on the Role of Drug Therapy in Non-Ulcer Dyspepsia","volume":"3","author":"Talley N. 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