{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:42:46Z","timestamp":1772995366230,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":328,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Eosinophilic esophagitis (EoE) is a chronic immune\u2010mediated disease and a leading cause of food impaction in pediatric populations, with potential functional and structural complications. Proton\u2010pump inhibitors (PPIs) are widely used as first\u2010line therapy, but the response rate in Colombian children remains unknown. This study aimed to determine the initial histologic response to PPI therapy and describe clinical, endoscopic, and histological characteristics in a sample of pediatric patients with EoE from Bogot\u00e1, Colombia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>A retrospective observational longitudinal study of patients aged 2\u201318\u2009years diagnosed with EoE at a tertiary care center between 2015 and 2022 was conducted. Patients underwent initial clinical and endoscopic assessment confirming esophageal eosinophilia (\u2265 15 eosinophils per high\u2010power field [eos\/hpf]), followed by at least 8\u2010week course of PPI therapy and a subsequent clinical\u2010endoscopic re\u2010evaluation. Treatment response was defined histologically as &lt; 15 eos\/hpf in follow\u2010up esophageal biopsy. Demographic, clinical, endoscopic, and histological data were analyzed using descriptive and bivariate statistics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 34 patients (median age 11\u2009years; 61.8% boys). Sixteen (47%) achieved histological remission with initial PPI therapy. Being esomeprazole preferred in 88%, with median dose 1.37\u2009mg\/kg\/day. No significant differences were observed between responders and nonresponders in demographic variables, familial and personal atopic history, symptoms, or endoscopic findings. Histologically, responders demonstrated significant reductions in eosinophil counts, as well as improvements in basal zone hyperplasia, eosinophilic abscesses, and eosinophil surface layering (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This is the first study to assess PPI response in Colombian pediatric EoE patients, demonstrating a response rate consistent with existing literature. Histologic evaluation was identified as the most reliable marker of treatment success, underscoring the critical role of histopathological follow\u2010up in this disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cjgh\/4633813","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T09:19:38Z","timestamp":1764062378000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Response to Proton\u2010Pump Inhibitors Therapy in Pediatric Patients With Eosinophilic Esophagitis in Bogot\u00e1, Colombia"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3395-3521","authenticated-orcid":false,"given":"Andrea Estefan\u00eda","family":"Rodr\u00edguez L\u00f3pez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3028-5222","authenticated-orcid":false,"given":"Jos\u00e9 Fernando","family":"Vera Chamorro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6655-9216","authenticated-orcid":false,"given":"Ailim Margarita","family":"Carias Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1443-4649","authenticated-orcid":false,"given":"M\u00f3nica Viviana","family":"Pinilla Roncancio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7277-7482","authenticated-orcid":false,"given":"Roc\u00edo del Pilar","family":"L\u00f3pez Panqueva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9476-3501","authenticated-orcid":false,"given":"Gonzalo Andr\u00e9s","family":"Monta\u00f1o Rozo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0b013e3182a80be1"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.009"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-021-01178-2"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/children10101598"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rgmx.2018.08.001"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.017"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.2147\/jaa.s274524"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15957"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301817"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.12.019"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12470"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000001019"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000003530"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.07.042"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2019.05.005"}],"container-title":["Canadian 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