{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:47:14Z","timestamp":1776844034384,"version":"3.51.2"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":110,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the efficacy of internet\u2010based interventions in improving clinical outcomes among patients with nonalcoholic fatty liver disease (NAFLD) and to synthesize evidence for future research directions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search of nine electronic databases (CNKI, Wanfang, VIP, CBM, PubMed, Web of Science, Cochrane Library, Embase, and CINAHL) was conducted from inception to September 23, 2024, to identify randomized controlled trials (RCTs) assessing internet\u2010based lifestyle interventions in NAFLD patients. Two independent researchers screened studies, extracted data, and evaluated methodological quality. Meta\u2010analyses were performed using RevMan 5.3.5 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten RCTs involving 714 participants were included. Compared to the control group, the intervention groups showed significant reductions in BMI, ALT and AST. Weight loss trended toward reduction but was not statistically significant, though subgroup analysis showed significant weight loss in interventions lasting &gt; 3\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Internet\u2010based interventions significantly improve BMI and liver enzymes in NAFLD patients, with prolonged interventions (&gt; 3\u2009months) enhancing weight loss. Digital platforms show promise for enhancing self\u2010management, though standardized long\u2010term trials are needed to optimize efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cjgh\/5125598","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:34:20Z","timestamp":1776839660000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Internet\u2010Based Lifestyle Interventions on Nonalcoholic Fatty Liver Disease: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6920-6376","authenticated-orcid":false,"given":"Chengjie","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3475-7068","authenticated-orcid":false,"given":"Yilong","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9875-4172","authenticated-orcid":false,"given":"Jingjing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8568-8199","authenticated-orcid":false,"given":"Hua","family":"Mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.21037\/hbsn-23-556"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(22)00165-0"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.040"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/hep.0000000000000323"},{"key":"e_1_2_13_5_2","first-page":"418","article-title":"Guidelines for the Prevention and Treatment of Metabolic-Associated (non-Alcoholic) Fatty Liver Disease (2024 Edition)","volume":"32","author":"Chinese Society of Hepatology","year":"2024","journal-title":"Chinese Journal of Hepatology"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.05.053"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323082"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.09.021"},{"key":"e_1_2_13_9_2","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jhep.2015.11.004","article-title":"Easl-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease","volume":"64","author":"European Association for the Study of the Liver (Easl)","year":"2016","journal-title":"Journal of Hepatology"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu16131996"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-018-0591-0"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.02.011"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.2196\/14802"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.02.003"},{"key":"e_1_2_13_15_2","volume-title":"Literature Search Strategies[M]\/\/Hearing Loss in Adults: Assessment and Management","author":"Centre (Uk) N G","year":"2018"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare12232488"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-024-00968-8"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2021.03.031"},{"key":"e_1_2_13_19_2","article-title":"Mobile App\u2013based Lifestyle Coaching Intervention for Patients With Nonalcoholic Fatty Liver Disease","volume":"26","author":"Kwon O. 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