{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T10:45:48Z","timestamp":1782643548281,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":178,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CORPG8N0271"],"award-info":[{"award-number":["CORPG8N0271"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatocellular carcinoma (HCC) is a lethal cancer. Early recurrence, i.e., recurrence within two years of curative treatment, is a major determinant of ultimate survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We included 625 patients with newly diagnosed early\u2010stage HCC, i.e., Barcelona Clinic Liver Cancer (BCLC) Stage 0 or A, and Child\u2013Pugh Class A liver disease who underwent percutaneous radiofrequency ablation (RFA) between 2011 and 2021 at our institution with a follow\u2010up period of &gt;\u20092\u2009years. The patients were divided into Group 1 (patients who developed nonlocal recurrence or died within two years after RFA;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009300 [48.0%]) and Group 2 (patients who developed local recurrence within two years or were recurrence\u2010free and were alive for two years after RFA;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009325 [52.0%]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Multivariate analysis showed that a Model for End\u2010Stage Liver Disease (MELD) score of &gt;\u20099, anti\u2010hepatitis C virus (HCV) positivity, the presence of image\u2010defined cirrhosis, treatment with antiviral therapies for hepatitis B virus or HCV, alpha\u2010fetoprotein \u2265\u200920\u2009ng\/mL, multiple tumors, and larger tumor size were independent factors associated with Group 1. A nomogram was developed based on these variables to predict Group 1, with a concordance index of 68.3% (95% CI\u2009=\u200964.1%\u201372.5%). The 10\u2010year overall survival of Group 1 was 28%, and that of Group 2 was 64%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We developed a nomogram to predict true early recurrence (i.e., nonlocal recurrence) of HCC after RFA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cjgh\/8778095","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T10:16:01Z","timestamp":1782641761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Group Stratification for True Early Recurrence After Ablation for Hepatomas"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6251-7230","authenticated-orcid":false,"given":"Yi-Hao","family":"Yen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwong-Ming","family":"Kee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-9519","authenticated-orcid":false,"given":"Chao-Hung","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-8133","authenticated-orcid":false,"given":"Chien-Hung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Hui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-9814","authenticated-orcid":false,"given":"Jing-Houng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5493-4752","authenticated-orcid":false,"given":"Sheng-Nan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"e_1_2_14_1_2","volume-title":"Taiwan 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