{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:11:47Z","timestamp":1789207907212,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":254,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006402","name":"Fasa University of Medical Sciences","doi-asserted-by":"publisher","award":["403185"],"award-info":[{"award-number":["403185"]}],"id":[{"id":"10.13039\/501100006402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    The escalating global threat of antibiotic resistance underscores the urgent need for innovative antimicrobial strategies in wound management. In this regard, the integration of herbal therapeutics with noble metal nanoparticles, particularly silver, represents a promising combined approach for both infection control and tissue regeneration. In the present study, a novel nanogel system for advanced wound healing was developed through the incorporation of\n                    <jats:italic>Zataria multiflora<\/jats:italic>\n                    essential oil (ZMEO) with silver nanoparticles (AgNPs). Three carboxymethyl cellulose (CMC)\u2013based hydrogel formulations were prepared, including an AgNP\u2010loaded hydrogel, a ZM\u2010loaded nanogel (ZM\u2010NGEL), and a hybrid nanogel (ZM\u2010Ag\u2010NGEL). Comprehensive physicochemical characterization demonstrated favorable formulation attributes. The primary nanoemulsions and AgNPs exhibited uniform nanoscale dimensions of 155\u2009\u00b1\u20097 and 53\u2009\u00b1\u20096\u2009nm, respectively, along with strongly negative zeta potentials, indicative of excellent colloidal stability. Structural analyses using scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy confirmed successful component integration and the formation of a polymeric network within the hybrid formulation. Rheological evaluation revealed pronounced shear\u2010thinning behavior and enhanced zero\u2010shear viscosity, most notably in the ZM\u2010Ag\u2010NGEL system. Functionally, the hybrid nanogel displayed superior, dose\u2010dependent, broad\u2010spectrum antibacterial activity against\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    , and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , significantly outperforming the single\u2010component formulations. Collectively, these findings demonstrate that the ZM\u2010Ag\u2010NGEL system effectively combines the wound\u2010healing potential of\n                    <jats:italic>Zataria multiflora<\/jats:italic>\n                    with the potent antimicrobial activity of AgNPs within a stable hydrogel matrix, thereby positioning it as a promising antimicrobial platform for further investigation in topical and biomedical applications.\n                  <\/jats:p>","DOI":"10.1155\/cjid\/2543116","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:04:17Z","timestamp":1789207457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Zataria multiflora<\/i>\n                    Essential Oil\u2013Silver Nanoparticle Hybrid Nanogel: A Dual\u2010Action Platform With Enhanced Antimicrobial Activity as a Promising Topical Antimicrobial System"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1190-6874","authenticated-orcid":false,"given":"Mahmoud","family":"Osanloo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-8962","authenticated-orcid":false,"given":"Ali","family":"Taghinezhad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6985-562X","authenticated-orcid":false,"given":"Mohabbat","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0915-8088","authenticated-orcid":false,"given":"Fatemeh","family":"Noorbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najmeh","family":"Namdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2805-1910","authenticated-orcid":false,"given":"Elham","family":"Zarenezhad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114671"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2017.07.012"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.09.045"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21210"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.130610"},{"key":"e_1_2_12_6_2","first-page":"277","article-title":"The Antibiotic Resistance Crisis: Part 1: Causes and Threats","volume":"40","author":"Ventola C. 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