{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:16:36Z","timestamp":1788387396219,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":229,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["KTPYJ2023002"],"award-info":[{"award-number":["KTPYJ2023002"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To analyze the prevalence of human immunodeficiency virus type 1 (HIV\u20101) drug resistance mutations (DRMs) and compare the therapeutic outcomes of different antiretroviral treatment regimens in newly diagnosed HIV\u20101\u2010infected patients with the V179D\/E mutation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study included newly diagnosed HIV\u20101\u2010infected individuals in Guangzhou from 2020 to 2024. Peripheral venous blood samples were collected, and viral RNA was extracted. The\n                      <jats:italic>pol<\/jats:italic>\n                      region of HIV genome was amplified and sequenced. Genotypic resistance testing was performed on the obtained\n                      <jats:italic>pol<\/jats:italic>\n                      gene sequences, and the prevalence of DRMs was analyzed. The efficacy of efavirenz (EFV)\u2010based and non\u2010EFV\u2010based regimens in patients with V179D\/E mutation was compared using cumulative failure rate curves.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 740 enrolled patients who underwent baseline resistance testing, 198 (26.76%) harbored DRMs, of whom 59 (7.97%) exhibited pretreatment drug resistance (PDR). The predominant HIV subtypes were CRF07_BC and CRF01_AE. Non\u2010nucleoside reverse transcriptase inhibitors (NNRTIs) were associated with a DRM prevalence rate of 22.16% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009164\/740), with common mutation sites being V179E (45.96%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200991\/198) and V179D (12.12%,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924\/198). 58.9% of patients with V179D\/E mutations received EFV\u2010based regimens (EFV group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200966\/112), while 41.1% (46\/112) used integrase strand transfer inhibitors (INSTIs) or protease inhibitors (PIs)\u2010based regimens (non\u2010EFV group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200946). Besides, the EFV group exhibited significantly higher treatment failure rates than the non\u2010EFV group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0131).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of DRMs in newly diagnosed HIV\u20101\u2010infected individuals in Guangzhou associated with NNRTIs is 22.16%, primarily driven by the V179D\/E mutation. EFV\u2010based treatments were associated with higher cumulative virological failure rates in patients with V179D\/E mutation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cjid\/2598894","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T21:55:02Z","timestamp":1787090102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of HIV Drug Resistance Mutations Along With Treatment Outcomes of Efavirenz\u2010Based Regimens in Patients With V179D\/E Mutations in Guangzhou, China"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4132-5745","authenticated-orcid":false,"given":"Xingrong","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3988-8501","authenticated-orcid":false,"given":"Yunfei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2324-8570","authenticated-orcid":false,"given":"Yeqiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5397-5579","authenticated-orcid":false,"given":"Peipei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6839-7705","authenticated-orcid":false,"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0552-7250","authenticated-orcid":false,"given":"Lili","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9415-6089","authenticated-orcid":false,"given":"Yue","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2177-3590","authenticated-orcid":false,"given":"Xiaodi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2984-9695","authenticated-orcid":false,"given":"Dabiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9515-8217","authenticated-orcid":false,"given":"Xiaohua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4405-244X","authenticated-orcid":false,"given":"Zhanlian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1915826"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.24543"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000344"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.4081\/idr.2013.s1.e5"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/v10010041"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283427dcb"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06847-5"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.965836"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25411"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-022-00723-8"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/v15101992"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.40139"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1033098"},{"key":"e_1_2_13_14_2","volume-title":"Testing, 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