{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T12:46:06Z","timestamp":1776516366856,"version":"3.51.2"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":107,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The global emergence of multidrug\u2010resistant (MDR)\n                      <jats:italic>Salmonella enterica<\/jats:italic>\n                      poses a significant public health threat, particularly in developing countries where antibiotic consumption remains high. However, genomic data on circulating\n                      <jats:italic>Salmonella<\/jats:italic>\n                      strains in Eastern China remain limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To characterize the genomic profiles of antimicrobial resistance (AMR) and molecular epidemiology of\n                      <jats:italic>Salmonella<\/jats:italic>\n                      isolates from diarrheal patients in Jinan, China (2017\u20132020).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 185\n                      <jats:italic>Salmonella<\/jats:italic>\n                      strains isolated from secondary\/tertiary hospital outpatients were subjected to whole genome sequencing (WGS) on the Illumina platform. Bioinformatic analyses included antimicrobial resistance gene (ARG) screening (ResFinder and CARD), multilocus sequence typing (MLST), in silico serotyping (SISTR), and pan\u2010genome analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All isolates exhibited multidrug resistance, with highest rates to fluoroquinolones (100%), aminoglycosides (99.46%), and nitroimidazoles (99.46%). ARG profiling revealed aac(6\u2032)\u2010Iaa as the predominant gene (98.9%). MLST identified 33 sequence types (STs), dominated by ST34 (28.65%) and ST11 (24.86%). In silico serotyping further confirmed the predominance of the monophasic\n                      <jats:italic>Salmonella Typhimurium<\/jats:italic>\n                      (I 1,4, [5],12:i:\u2010; ST34) and\n                      <jats:italic>Salmonella Enteritidis<\/jats:italic>\n                      (ST11). Pan\u2010genome analysis defined a core genome of 3376 genes (23.35%) and an accessory genome of 9201 cloud genes (63.64%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This first WGS\u2010based surveillance in Jinan highlights the predominance of MDR ST34\/ST11\n                      <jats:italic>Salmonella<\/jats:italic>\n                      with an extremely high prevalence (100%) of fluoroquinolone resistance. The integration of genomic and historical phenotypic data underscores the urgent need to revise empirical therapy for diarrheal diseases and implement genomic surveillance in public health practice.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cjid\/5033217","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T11:56:41Z","timestamp":1776513401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole Genome Sequencing Reveals High Prevalence of Antimicrobial Resistance Genes in\n                    <i>Salmonella<\/i>\n                    Isolates From Diarrheal Patients in Jinan, China"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1125-2808","authenticated-orcid":false,"given":"Chuanmin","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8911-911X","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0688-544X","authenticated-orcid":false,"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9463-3064","authenticated-orcid":false,"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"e_1_2_11_1_2","article-title":"Research Progress of Drugs for the Treatment of drug-resistant Bacteria","volume":"14","author":"Ma Y. 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