{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:20:39Z","timestamp":1787556039517,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":234,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Background<\/jats:title>\n Kaposi\u2019s sarcoma\u2013associated herpesvirus (KSHV) seropositivity is prevalent in people with HIV (PWH), yet its association with immune reconstitution during long\u2010term ART remains unclear.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this retrospective cohort study, we reviewed the records of 209 virally suppressed PWH (VL\u2009<\u200950 copies\/mL) after \u2265\u20092\u2009years of ART. Participants were stratified based on their KSHV serostatus (IgG+). Data on immune parameters were extracted from laboratory reports corresponding to the 2\u2010year post\u2010ART time point.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n KSHV seropositive individuals exhibited significantly lower CD4\n +<\/jats:sup>\n counts (101.5 vs. 316.0\u2009cells\/\u03bcL;\n p<\/jats:italic>\n < 0.001), reduced CD4\/CD8 ratios (0.26 vs. 0.60;\n p<\/jats:italic>\n < 0.001), and elevated IL\u20106 (9.78 vs. 5.46\u2009pg\/mL;\n p<\/jats:italic>\n < 0.001). Multivariate analysis identified IL\u20106 as an independent predictor of seropositivity (OR\u2009=\u20091.238;\n p<\/jats:italic>\n < 0.001). The combination of CD4\n +<\/jats:sup>\n (\u2264\u2009126\u2009cells\/\u03bcL) and IL\u20106 (>\u20095.83\u2009pg\/mL) showed superior diagnostic accuracy for KSHV seropositivity (AUC\u2009=\u20090.832).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n KSHV seropositivity correlates with impaired immune reconstitution in virally suppressed PWH. CD4\n +<\/jats:sup>\n and IL\u20106 may jointly serve as a screening tool for KSHV serostatus assessment, though their utility for detecting active infection requires further study.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1155\/cjid\/5156452","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:36:48Z","timestamp":1787553408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["KSHV Seropositivity Associates With Impaired Immune Reconstitution in Virally Suppressed HIV"],"prefix":"10.1155","volume":"2026","author":[{"given":"Xiaowu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuantuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqi","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6877-5791","authenticated-orcid":false,"given":"Linding","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaf229"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.20411\/pai.v10i1.788"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2025.117037"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-79449-1"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.4MR1019-189R"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328339cf40"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835cb747"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.001"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv148"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.1.110304.100133"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000330"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328182df03"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.01.003"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2020.11.005"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad160"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24960"}],"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cjid\/5156452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/cjid\/5156452","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cjid\/5156452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:36:49Z","timestamp":1787553409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/cjid\/5156452"}},"subtitle":[],"editor":[{"given":"Satabdi","family":"Datta Choudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/cjid\/5156452"],"URL":"https:\/\/doi.org\/10.1155\/cjid\/5156452","archive":["Portico"],"relation":{},"ISSN":["1712-9532","1918-1493"],"issn-type":[{"value":"1712-9532","type":"print"},{"value":"1918-1493","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication 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