{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:40:16Z","timestamp":1773013216136,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":86,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    With emerging antibiotic resistance, many patients on peritoneal dialysis require newer antibiotic treatment such as daptomycin. Inadequate clinical information exists across different peritoneal dialysis solutions, including icodextrin, for the stability of intraperitoneal daptomycin. To guide the clinical practice of intraperitoneal daptomycin treatment, we need to establish the stability of daptomycin at dextrose concentration higher than 1.5% and icodextrin, as well as the duration of stability.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    We tested the stability of daptomycin in three types of peritoneal dialysis bags (UltraBag dextrose 2.5%, UltraBag icodextrin 7.5%, and Stay\u2010Safe Balance 2.3%). Daptomycin was reconstituted with water for injection (50\u2009mg\/mL), followed by administration to peritoneal dialysis bags to obtain the final daptomycin concentrations of 70\u2009\u03bcg\/mL (equivalent to 140\u2009mg\/2L, the maintenance level) and 245\u2009\u03bcg\/mL (equivalent to 490\u2009mg\/2L, the loading level). The bags were then placed at ambient temperature (25\u00b0C) followed by withdrawing 5\u2009mL samples at 0, 4, 8, 12, 24, and 48\u2009h for UltraBag dextrose 2.5% and UltraBag icodextrin 7.5% and 0, 4, 8, 12, and 24\u2009h for Stay\u2010Safe Balance 2.3%. The concentrations of daptomycin in the collected samples were quantified by high\u2010performance liquid chromatography with diode array detector (HPLC\u2010DAD).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Under ambient condition, daptomycin was stable at maintenance level in UltraBag dextrose 2.5% for 48\u2009h and in UltraBag icodextrin 7.5% or Stay\u2010Safe Balance 2.3% for 24\u2009h. For loading level, daptomycin was stable in UltraBag dextrose 2.5% and Stay\u2010Safe Balance 2.3% for 12\u2009h and in UltraBag icodextrin 7.5% for 48\u2009h.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Current stability results support and guide the use of intraperitoneal daptomycin in different dialysis solutions. Patients with peritonitis requiring icodextrin exchange and assisted preparation of daptomycin can benefit from nurses who provide daily home visit based on our stability results.\n                  <\/jats:p>","DOI":"10.1155\/cjid\/5553355","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T03:35:32Z","timestamp":1743132932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stability of Daptomycin in Dextrose and Icodextrin\u2010Based Peritoneal Dialysis Solutions"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5310-5197","authenticated-orcid":false,"given":"Kai Ming","family":"Chow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siu Kwan","family":"Wo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon Wai Yin","family":"So","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyllis Mei Shan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5054-4290","authenticated-orcid":false,"given":"Keary Rui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai Li","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6976-6157","authenticated-orcid":false,"given":"Joan Zhong","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9879-8388","authenticated-orcid":false,"given":"Philip Kam Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000000000000280"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/08968608221080586"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2016.12.002"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S433439"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefro.2015.11.001"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq118"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2014.00271"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2017.00256"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2016.00028"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000328028"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42770-019-00200-4"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/1120009X.2024.2407705"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/08968608231196034"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-023-01716-7"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ejhpharm-2015-000651"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2012.00120"},{"key":"e_1_2_11_17_2","unstructured":"InmanE. 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Inventor; an Improved Diluent Formulation for Daptomycin 1990."},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00183"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/08968608231172740"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu033"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/08968608241274096"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/08968608241283526"}],"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cjid\/5553355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/cjid\/5553355","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cjid\/5553355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:22:37Z","timestamp":1773008557000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/cjid\/5553355"}},"subtitle":[],"editor":[{"given":"Mejdi","family":"Snoussi","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/cjid\/5553355"],"URL":"https:\/\/doi.org\/10.1155\/cjid\/5553355","archive":["Portico"],"relation":{},"ISSN":["1712-9532","1918-1493"],"issn-type":[{"value":"1712-9532","type":"print"},{"value":"1918-1493","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5553355"}}