{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:03:00Z","timestamp":1789707780519,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":259,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The recent COVID\u201019 pandemic has resulted in a wide spectrum of neurological complications, including stroke, and emerging evidence suggests a critical role of microRNAs in their development. This study aimed to evaluate the expression levels of miR\u2010124, miR\u2010636, and miR\u2010485\u20105p in COVID\u201019 patients with and without stroke, compared with healthy individuals, to investigate their potential roles in COVID\u201019\u2010associated neurological manifestations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included 100 individuals: 25 COVID\u201019 patients with stroke, 25 COVID\u201019 patients without stroke, and 50 healthy controls. COVID\u201019 infection was confirmed using RT\u2010PCR. Following plasma isolation and RNA extraction, quantitative real\u2010time PCR was performed to determine the expression levels of miR\u2010124, miR\u2010636, and miR\u2010485\u20105p. The Kruskal\u2013Wallis test followed by Dunn\u2019s post hoc test was used for statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The miR\u2010124 expression was significantly increased in the stroke\u2010positive group (5.13\u2009\u00b1\u20092.48) compared to both the stroke\u2010negative (1.78\u2009\u00b1\u20091.03) and control groups (1.69\u2009\u00b1\u20090.64) (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0084). Significant differences were observed between the stroke\u2010positive and stroke\u2010negative groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0156), as well as between the stroke\u2010positive and control groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0333). Although not statistically significant, a trend toward increased levels was observed in the stroke\u2010positive group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.3594). miR\u2010636 showed no significant differences among the three groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.9987). miR\u2010485\u20105p showed a nonsignificant trend toward higher levels in stroke\u2010positive patients (2.15\u2009\u00b1\u20091.53 vs. 1.38\u2009\u00b1\u20091.01,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.36).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results demonstrated a significant overexpression of miR\u2010124 in COVID\u201019 patients with stroke, highlighting its potential role in COVID\u201019\u2010associated neurological disorders. Further studies are required to elucidate the underlying mechanisms and assess its potential as a diagnostic and therapeutic biomarker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cjid\/5657680","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:07:09Z","timestamp":1789704429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Interplay Between COVID\u201019 and Stroke: Experimental Insights Into MicroRNA\u2010Regulated Neuroinflammation"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3369-0856","authenticated-orcid":false,"given":"Saber","family":"Soltani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2145-0196","authenticated-orcid":false,"given":"Milad","family":"Zandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5340-0529","authenticated-orcid":false,"given":"Habibollah","family":"Mirzaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3117-6669","authenticated-orcid":false,"given":"Saeedeh","family":"Ebrahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid 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