{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T09:05:38Z","timestamp":1768208738953,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Most evidence on ventilator\u2010associated pneumonia (VAP)\u2013related and ventilator\u2010associated tracheobronchitis (VAT)\u2013related mortality comes from general ICU settings, with limited data on critically ill cancer patients. This study aimed to characterize the microbiological profile and resistance patterns in an oncology hospital and evaluate their impact on 14\u2010day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of VAP and VAT cases in an oncology ICU in Brazil (Jan\u2013Dec 2024), assessing bacterial frequency, multidrug\u2010resistant organisms (MDRO), and mortality. Multivariate analysis was used to identify the variables significantly associated with mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 85 ICU patients, tracheobronchitis was more frequent (59%) than pneumonia (41%). Most were male (61%) with a median age of 62\u2009years and had solid tumors (85%), mainly in the lungs and neck. Of 109 samples,\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      (27%),\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      (20%), and\n                      <jats:italic>S. maltophilia<\/jats:italic>\n                      (17%) were the most common pathogens. MDRO was particularly high in\n                      <jats:italic>A. baumannii<\/jats:italic>\n                      (82%). Overall, 14\u2010day mortality was 55%. MDR was not associated with mortality (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.3), but VAP (OR 4.20,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004) and infections with positive blood culture (OR 5.38,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.023) were independently associated with mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides valuable insights into the microbiological profile of patients with VAP and VAT in an oncological ICU and its impact on mortality. Mortality was not associated with MDR, possibly reflecting the high baseline risk from underlying conditions. However, patients with positive blood cultures had significantly higher mortality, suggesting a more invasive disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cjid\/5887462","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T06:03:21Z","timestamp":1768197801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mortality in Ventilator\u2010Associated Tracheobronchitis and Pneumonia in Oncology Patients: The Impact of Microbiological Aspects"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2097-389X","authenticated-orcid":false,"given":"Vitor Falcao de","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora de Oliveira","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdirene Santos Folli","family":"Cabral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Dalfior","family":"Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Siqueira","family":"Matos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Alexandra Ant\u00f4nia de","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Vasconcelos","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Manoel da Silva","family":"Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"Cury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odeli Nicole Encinas","family":"Sejas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Satie Gon\u00e7alves Kono","family":"Magri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson","family":"Abdala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05980-0"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.4066\/AMJ.2014.2105"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlad140"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-023-07086-9"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw353"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.12222.1"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1754"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50805-z"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-24-150"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.09.025"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e3325"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.17058\/reci.v5i1.4885"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200405-644ST"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132006000400013"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70081-1"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.5492\/wjccm.v9.i3.43"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.14.5787"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-017-0509-8"},{"key":"e_1_2_12_19_2","unstructured":"Pneumonia (Ventilator-Associated [VAP] and Non-Ventilator-Associated Pneumonia [PNEU]) Event [Internet] 2025 https:\/\/www.cdc.gov\/nhsn\/pdfs\/pscmanual\/6pscvapcurrent.pdf."},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.03.002"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2007.10.006"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1017\/s0195941700060355"},{"key":"e_1_2_12_23_2","volume-title":"Contemporary Topics of Pneumonia","author":"Monteiro-Neto V.","year":"2017"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60081346"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.02173"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01070-08"},{"key":"e_1_2_12_27_2","volume-title":"Infection Control Guideline for the Prevention of Healthcare-Associated Pneumonia","author":"Public Health Agency of Canada (PHAC)","year":"2010"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0195-6701(95)90049-7"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/593289"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw172.960"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.2_suppl.373s"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-015-0077-4"}],"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cjid\/5887462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T06:03:23Z","timestamp":1768197803000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/cjid\/5887462"}},"subtitle":[],"editor":[{"given":"Arif","family":"Ansori","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/cjid\/5887462"],"URL":"https:\/\/doi.org\/10.1155\/cjid\/5887462","archive":["Portico"],"relation":{},"ISSN":["1712-9532","1918-1493"],"issn-type":[{"value":"1712-9532","type":"print"},{"value":"1918-1493","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5887462"}}