{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:34:49Z","timestamp":1790962489041,"version":"4.1.0"},"reference-count":109,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":162,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Neurolisteriosis is a listerial invasive disease, which is characterized by brain parenchymal and meningeal involvement, with a high fatality rate and frequent neurological sequelae. The main clinical presentations of neurolisteriosis are meningitis, meningoencephalitis, rhombencephalitis, and brain abscess. Neuroradiological imaging is useful to distinguish these clinical presentations. The diagnosis of neurolisteriosis may be confirmed by cerebrospinal fluid or blood cultures, but these tests may have different yields depending on the clinical presentation of neurolisteriosis. The elderly and immunocompromised patients are the most susceptible population to developing neurolisteriosis, and few cases occur in healthy young people. This disease is caused by\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    , a foodborne pathogen with an intracellular life cycle, which can be found in processed foods, and it remains the third cause of bacterial meningitis in adults. Most cases of neurolisteriosis are community\u2010acquired, but several hospital\u2010acquired cases and outbreaks have been reported in the literature and linked to the consumption of food served to inpatients. Aminopenicillins are the antibiotics with the highest impact on the prognosis of neurolisteriosis, and alternative antimicrobial therapies must be considered in those cases where a first\u2010choice antibiotic cannot be administered or with antibiotic treatment failure. In this article, the epidemiology, sources of infection, pathogenesis, and clinical aspects of neurolisteriosis are reviewed, highlighting the main clinical presentations of the disease. Relevant information regarding hospital\u2010acquired neurolisteriosis is also included to provide a framework for discussing nosocomial cases definition.\n                  <\/jats:p>","DOI":"10.1155\/cjid\/5960643","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T10:34:37Z","timestamp":1749724477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Presentations and Nosocomial Infections of Neurolisteriosis"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3644-2770","authenticated-orcid":false,"given":"Javier Vicente","family":"Trejos Pino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Rodriguez Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"e_1_2_17_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-008-0049-0"},{"key":"e_1_2_17_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00060-19"},{"key":"e_1_2_17_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.afnr.2018.02.006"},{"key":"e_1_2_17_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01146.x"},{"key":"e_1_2_17_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-014-0636-y"},{"key":"e_1_2_17_6_2","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/704321"},{"key":"e_1_2_17_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit250"},{"key":"e_1_2_17_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-324"},{"key":"e_1_2_17_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.24802"},{"key":"e_1_2_17_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408390701856272"},{"key":"e_1_2_17_11_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.19586"},{"key":"e_1_2_17_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70870-9"},{"key":"e_1_2_17_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1278860"},{"key":"e_1_2_17_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods12152956"},{"key":"e_1_2_17_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ram.2021.02.013"},{"key":"e_1_2_17_16_2","doi-asserted-by":"publisher","DOI":"10.4315\/JFP-20-271"},{"key":"e_1_2_17_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp180"},{"key":"e_1_2_17_18_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0803.010195"},{"key":"e_1_2_17_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2019.08.072"},{"key":"e_1_2_17_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu365"},{"key":"e_1_2_17_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2016.2274"},{"key":"e_1_2_17_22_2","first-page":"210","article-title":"Epidemiology and Treatment of the Commonest Form of Listeriosis: Meningitis and Bacteraemia","volume":"25","author":"Pagliano P.","year":"2017","journal-title":"Informe Medico"},{"key":"e_1_2_17_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27069-y"},{"key":"e_1_2_17_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10050591"},{"key":"e_1_2_17_25_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268815003039"},{"key":"e_1_2_17_26_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268816003198"},{"key":"e_1_2_17_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-017-1043-1"},{"key":"e_1_2_17_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.09.020"},{"key":"e_1_2_17_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2010.08.007"},{"key":"e_1_2_17_30_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268815002563"},{"key":"e_1_2_17_31_2","doi-asserted-by":"publisher","DOI":"10.5694\/mja14.00913"},{"key":"e_1_2_17_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2012.06.011"},{"key":"e_1_2_17_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2009.06.011"},{"key":"e_1_2_17_34_2","doi-asserted-by":"publisher","DOI":"10.1086\/315453"},{"key":"e_1_2_17_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2009.01.012"},{"key":"e_1_2_17_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis817"},{"key":"e_1_2_17_37_2","doi-asserted-by":"publisher","DOI":"10.1086\/658943"},{"key":"e_1_2_17_38_2","first-page":"1","article-title":"Commission Regulation (EC) No 2073\/2005 of 15 November 2005 on Microbiological Criteria for Foodstuffs","volume":"338","author":"Commission of the European Communities","year":"2005","journal-title":"Official Journal of the European Union"},{"key":"e_1_2_17_39_2","doi-asserted-by":"publisher","DOI":"10.1086\/676439"},{"key":"e_1_2_17_40_2","unstructured":"Government of South Australia Department of Health Guideline for the Control of Listeria in Food Service to Vulnerable Persons 2024 https:\/\/www.sahealth.sa.gov.au\/wps\/wcm\/connect\/b0edbe9b-1498-49c0-a7d4-d7b704752b39\/241017+Final+Web+Version+Guideline+for+the+Control+of+Listeria+in+Food+Service+to+Vulnerable+Persons.pdf."},{"key":"e_1_2_17_41_2","unstructured":"Government of the United Kingdom Food Standards Agency Reducing the Risk of Vulnerable Groups Contracting Listeriosis. Guidance for Healthcare and Social Care Organisations 2018 https:\/\/www.food.gov.uk\/sites\/default\/files\/media\/document\/listeria-guidance-june2016-rev.pdf."},{"key":"e_1_2_17_42_2","unstructured":"Food Standards Agency Project Reducing the Risk of Vulnerable Groups Contracting Listeriosis 2014 https:\/\/www.food.gov.uk\/sites\/default\/files\/media\/document\/fs101057report1litreview.pdf."},{"key":"e_1_2_17_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-018-5966-8"},{"key":"e_1_2_17_44_2","first-page":"2543","article-title":"Listeria monocytogenes","author":"Johnson J.","year":"2020","journal-title":"Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases"},{"key":"e_1_2_17_45_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/812648"},{"key":"e_1_2_17_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.55.3.476-511.1991"},{"key":"e_1_2_17_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/2.2.207"},{"key":"e_1_2_17_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2007.12.003"},{"key":"e_1_2_17_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.3.584-640.2001"},{"key":"e_1_2_17_50_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a010009"},{"key":"e_1_2_17_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2010.11.014"},{"key":"e_1_2_17_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.05.051"},{"key":"e_1_2_17_53_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2016-0221"},{"key":"e_1_2_17_54_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006472"},{"key":"e_1_2_17_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2016.08.001"},{"key":"e_1_2_17_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.GPP3-0013-2018"},{"key":"e_1_2_17_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.126"},{"key":"e_1_2_17_58_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6549496"},{"key":"e_1_2_17_59_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199809000-00002"},{"key":"e_1_2_17_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0090-3019(03)00056-9"},{"key":"e_1_2_17_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8572-2"},{"key":"e_1_2_17_62_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000026839"},{"key":"e_1_2_17_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw569"},{"key":"e_1_2_17_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00070-09"},{"key":"e_1_2_17_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2346-5"},{"key":"e_1_2_17_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101922"},{"key":"e_1_2_17_67_2","doi-asserted-by":"publisher","DOI":"10.1086\/508462"},{"key":"e_1_2_17_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30521-7"},{"key":"e_1_2_17_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-016-0939-2"},{"key":"e_1_2_17_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy449"},{"key":"e_1_2_17_71_2","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0000000000000212"},{"key":"e_1_2_17_72_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-011-0228-5"},{"key":"e_1_2_17_73_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301073280104"},{"key":"e_1_2_17_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis943"},{"key":"e_1_2_17_75_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1986.00360150134016"},{"key":"e_1_2_17_76_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-024-09295-z"},{"key":"e_1_2_17_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2018.e00455"},{"key":"e_1_2_17_78_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/248302"},{"key":"e_1_2_17_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.01.007"},{"key":"e_1_2_17_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00883-7"},{"key":"e_1_2_17_81_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040845"},{"key":"e_1_2_17_82_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v7.i4.538"},{"key":"e_1_2_17_83_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.3.1609-1620.1990"},{"key":"e_1_2_17_84_2","doi-asserted-by":"publisher","DOI":"10.1086\/425368"},{"key":"e_1_2_17_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.06.006"},{"key":"e_1_2_17_86_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199835030-00005"},{"key":"e_1_2_17_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0163-4453(96)92929-1"},{"key":"e_1_2_17_88_2","doi-asserted-by":"publisher","DOI":"10.1086\/428355"},{"key":"e_1_2_17_89_2","doi-asserted-by":"publisher","DOI":"10.2174\/157488607780598304"},{"key":"e_1_2_17_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.06.012"},{"key":"e_1_2_17_91_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000486"},{"key":"e_1_2_17_92_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00177-08"},{"key":"e_1_2_17_93_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/436349"},{"key":"e_1_2_17_94_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn001"},{"key":"e_1_2_17_95_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01211-07"},{"key":"e_1_2_17_96_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn232"},{"key":"e_1_2_17_97_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki059"},{"key":"e_1_2_17_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.05.011"},{"key":"e_1_2_17_99_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2009.0863"},{"key":"e_1_2_17_100_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/29.3.351"},{"key":"e_1_2_17_101_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/164.1.221"},{"key":"e_1_2_17_102_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10101206"},{"key":"e_1_2_17_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100800"},{"key":"e_1_2_17_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2022.115634"},{"key":"e_1_2_17_105_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens14030294"},{"key":"e_1_2_17_106_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14102"},{"key":"e_1_2_17_107_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-016-9705-6"},{"key":"e_1_2_17_108_2","first-page":"468","article-title":"Listeria monocytogenes Brain Abscess: Two Cases and Review of the Literature","volume":"44","author":"Limmahakhun S.","year":"2013","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"e_1_2_17_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2023.08.016"}],"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cjid\/5960643","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/cjid\/5960643","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cjid\/5960643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:23:26Z","timestamp":1773008606000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/cjid\/5960643"}},"subtitle":[],"editor":[{"given":"Satabdi","family":"Datta Choudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":109,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/cjid\/5960643"],"URL":"https:\/\/doi.org\/10.1155\/cjid\/5960643","archive":["Portico"],"relation":{},"ISSN":["1712-9532","1918-1493"],"issn-type":[{"value":"1712-9532","type":"print"},{"value":"1918-1493","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5960643"}}