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Can Tho, the fourth\u2010largest city in Vietnam\u2019s Mekong Delta, is highly vulnerable to climate change. This study characterizes dengue fever (DF) and identifies factors linked to severe disease in hospitalized patients from 2018 to 2019. We analyzed the clinical manifestations of 123 patients, along with blood count tests, RT\u2010PCR, the NS1 antigen rapid test, and ELISA for IgM and IgG antibodies, upon admission. The results revealed that 88.6% of dengue patients were under 15\u2009years, primarily treated at Can Tho Pediatric Hospital, with 66.7% experiencing secondary infections. Warning signs included high fever, rapid pulse, abdominal pain (54.4%), nausea\/vomiting (43.2%), and bleeding (5.7%). DEN\u20101, DEN\u20102, and DEN\u20104 circulated during the study, with DEN\u20101 predominating in 2018 (85.7%) and both DEN\u20101 and DEN\u20102 as primary causes in 2019 (52.2% and 39.1%, respectively). The DEN\u20102 serotype and secondary infections may significantly contribute to severe dengue, and further research on dengue immunity is essential for understanding the effects of dengue vaccination.<\/jats:p>","DOI":"10.1155\/cjid\/6410209","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:29:20Z","timestamp":1772972960000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of Hospitalized Patients With Dengue Fever in Can Tho City: A Cross\u2010Sectional Analysis, 2018\u20102019"],"prefix":"10.1155","volume":"2026","author":[{"given":"Thuy Thi Thu","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phuong Vu Mai","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang Le 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