{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:45:44Z","timestamp":1785739544062,"version":"3.56.0"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":213,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                      is a major contributor to antimicrobial resistance (AMR), particularly in hospitals. Its rising resistance presents significant clinical and economic concerns. This study evaluated the national burden and economic impact of\n                      <jats:italic>A<\/jats:italic>\n                      .\n                      <jats:italic>baumannii<\/jats:italic>\n                      infections in Iran from 2000 to 2021 using GBD 2021 AMR data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We estimated mortality and disability\u2010adjusted life years (DALYs) per 100,000 people with 95% UIs under two scenarios: resistant infections replaced by susceptible ones (attributable burden) and replaced by no infection (associated burden). Economic burden was calculated using GDP per capita and purchasing power parity (PPP)\u2013adjusted estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 2000 to 2021, total associated DALYs declined from 90,391.9 (95% UI: 80,178.0\u2013100,605.9) to 69,740.5 (65,132.4\u201374,348.6) and attributable DALYs from 35,284.5 (30,843.1\u201339,725.9) to 28,085.9 (25,415.9\u201330,755.9). However, associated deaths increased from 2019.5 (1870.3\u20132168.8) to 2523.7 (2322.5\u20132724.9), with neonates and individuals aged 50 years and older most affected. Bloodstream and lower respiratory infections contributed most to DALYs. Resistance remained highest for cephalosporins and carbapenems. The economic burden peaked in 2010 at 584.6 million PPP and decreased to 435.2 million in 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Although disease burden declined, rising mortality and resistance trends highlight the need for stronger infection control and stewardship to reduce\n                      <jats:italic>A. baumannii<\/jats:italic>\n                      \u2010related AMR in Iran.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cjid\/6786134","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:05:49Z","timestamp":1785737149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Burden and Economic Impact of Antimicrobial Resistance in\n                    <i>Acinetobacter baumannii<\/i>\n                    in Iran: A 2000\u20132021 Analysis"],"prefix":"10.1155","volume":"2026","author":[{"given":"Sina","family":"Golestani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5192-0435","authenticated-orcid":false,"given":"Ali","family":"Golestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaneh","family":"Akbarpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5538-7586","authenticated-orcid":false,"given":"Mohammadreza","family":"Salehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Seifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyhan","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7401-2237","authenticated-orcid":false,"given":"Maryam","family":"Shafaati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(24)00876-6"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/bjbs.2023.11387"},{"key":"e_1_2_13_3_2","unstructured":"5 World Health Organization 10 Global Health Issues to Track in 2021 https:\/\/www.who.int\/news-room\/spotlight\/10-global-health-issues-to-track-in-2021."},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-022-01159-y"},{"key":"e_1_2_13_5_2","article-title":"The Antimicrobial Resistance Situation in Iran: The National Initiative and R&D to Face AMR","volume":"2018","author":"Iran I.","year":"2018","journal-title":"AMR CONTROL"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.1153"},{"key":"e_1_2_13_7_2","volume-title":"Sustainable Development Goals","author":"Katila P.","year":"2019"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01054-w"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jam.15130"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2021.11.008"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01464-06"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.26719\/emhj.23.043"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1101.040001"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(24)00769-4"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(24)01867-1"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(21)02724-0"},{"key":"e_1_2_13_17_2","unstructured":"(Ihme) IfHMaE MICROBE (Measuring Infectious Causes and Resistance Outcomes for Burden Estimation) 2024 https:\/\/vizhub.healthdata.org\/microbe\/."},{"key":"e_1_2_13_18_2","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1016\/S0140-6736(16)30388-9","article-title":"Guidelines for Accurate and Transparent Health Estimates Reporting: The GATHER Statement","volume":"388","author":"Stevens G. 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