{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:28:40Z","timestamp":1792517320141,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":162,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Bloodstream infections (BSI) in ICU settings are associated with high morbidity, mortality, and healthcare costs. The ICU environment, with its high use of invasive devices and immunocompromised patients, fosters an increased risk for multidrug resistance (MDR) pathogens, complicating treatment strategies. Understanding the epidemiology and resistance patterns in these settings is essential for improving patient outcomes and guiding appropriate antimicrobial stewardship practices. This study retrospectively analyzed data from 640 blood culture samples collected in the ICU of the Affiliated Hospital of Jiaxing University between January 2021 and December 2023. The blood samples were appropriately collected and cultured. Matrix\u2010assisted laser desorption\/ionization time\u2010of\u2010flight (MALDI\u2010TOF) mass spectrometry was employed to identify the isolated strains. Antimicrobial sensitivity was assessed using the VITEK2 system, the Epsilometer test (E\u2010test), and the Kirby\u2013Bauer disk diffusion method. All statistical analyses were conducted using IBM SPSS Statistics 22.0. A total of 391 bacterial pathogens (61.1%) were isolated. The predominant pathogens causing BSI were Gram\u2010negative bacteria. The most prevalent pathogens during the period were coagulase\u2010negative\n                    <jats:italic>Staphylococci<\/jats:italic>\n                    (CoNS, 17.1%), followed by\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    (\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    , 13.6%),\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    spp (13.6%),\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (\n                    <jats:italic>E. coli<\/jats:italic>\n                    ,\n                    <jats:italic>1<\/jats:italic>\n                    2.3%),\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    (\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    , 8.4%), and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    , 5.1%). Among the antibiotics tested, tigecycline, linezolid, vancomycin, and quinupristin\/dalfopristin were effective against\n                    <jats:italic>Staphylococci<\/jats:italic>\n                    and\n                    <jats:italic>Enterococci<\/jats:italic>\n                    , although some CoNS strains exhibited resistance to vancomycin. Tigecycline showed effectiveness against the main gram\u2010negative bacteria. Furthermore, multiple hospitalizations, comorbidity with diabetes, and the use of a central venous catheter were identified as significant risk factors for multidrug\u2010resistant organisms (MDROs) in BSI cases. Pathogens isolated from the bloodstream of ICU patients exhibited significant drug resistance. We recommend strategies to mitigate the incidence of MDROs in BSI, including limiting the duration of hospital stays, closely monitoring underlying patient conditions, improving discharge plans, and strengthening transitional care, and prevent infections associated with central venous catheters.\n                  <\/jats:p>","DOI":"10.1155\/cjid\/7841940","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T10:35:15Z","timestamp":1749724515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bacteriological Spectrum and Drug Resistance Among Patients Associated With Bloodstream Infection in Intensive Care Units in the Affiliated Hospital of Jiaxing University From 2021 to 2023"],"prefix":"10.1155","volume":"2025","author":[{"given":"Yucheng","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinlong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6486-9883","authenticated-orcid":false,"given":"Weifeng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"e_1_2_12_1_2","volume-title":"Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report 2022","author":"World Health Organization","year":"2022"},{"key":"e_1_2_12_2_2","volume-title":"Drug-Resistant Infections: A Threat to Our Economic Future (Vol. 2): Final Report (English)","author":"Jonas O. 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