{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T10:06:55Z","timestamp":1779012415552,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":131,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We aim to investigate which of the comorbidities is associated with prolonged viral RNA shedding among hospitalized patients with COVID\u201019 illness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective cohort study of COVID\u201019 patients in Hasan Sadikin General Hospital, Bandung, from March 2020 to April 2022. Data of ORF1b Ct value measurements were collected from the 1\n                      <jats:sup>st<\/jats:sup>\n                      week to the 5\n                      <jats:sup>th<\/jats:sup>\n                      week and presented in a line plot to see the changes in the Ct values across the course of the disease stratified to each comorbidity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included a total of 279 patients with a median age of 55\u2010year\u2010old, and male patients were the majority included. However, 68% of the original cohort was excluded due to having only a single Ct result. Based on the ORF1b Ct value data, most patients within each comorbidity group demonstrated increasing Ct values from Week 1 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009135) to Week 5 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934). However, we found that the ORF1b Ct value in the HIV\u2013AIDS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912) and the autoimmune (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912) groups peaked and gradually declined. In the HIV\u2013AIDS ORF1b, Ct values declined after 2\u2009weeks (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) with a statistically significant difference compared to patients without comorbidity (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200965).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study shows that COVID\u201019 patients with HIV\u2013AIDS have prolonged viral shedding compared to patients with other comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cjid\/8871861","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:26:00Z","timestamp":1778577960000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Relationship Between Comorbidities and Prolonged Viral Shedding in COVID\u201019: A Cycle Threshold Value\u2010Based Investigation"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4520-9093","authenticated-orcid":false,"given":"Rudi","family":"Wisaksana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Philo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floriyani Indra","family":"Putri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4736-901X","authenticated-orcid":false,"given":"Chrisan Bimo","family":"Prayuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0178-7138","authenticated-orcid":false,"given":"Evan","family":"Susandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardus","family":"Widyatmoko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bachti","family":"Alisjahbana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iceu Dimas","family":"Kulsum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yovita","family":"Hartantri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.05.045"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-020-00324-3"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00799-2020"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0252217"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.02.117"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2021.1939891"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac077"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00822-w"},{"key":"e_1_2_12_9_2","volume-title":"Clinical Management of COVID-19: Living Guideline","author":"World Health Organization","year":"2023"},{"key":"e_1_2_12_10_2","unstructured":"RecommendationsU. 2018 Laboratory Testing for the Diagnosis of HIV Infection Updated Recommendations."},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.3182\/20140824-6-za-1003.01333"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz425"},{"key":"e_1_2_12_13_2","volume-title":"Pedoman Pengelolaan Dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia 2021","author":"Soelistijo S. 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