{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:42:35Z","timestamp":1773013355325,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":324,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    The Elecsys SARS\u2010CoV\u20102 antigen test (Elecsys; Roche Diagnostics, Rotkreuz, Switzerland) is a quantitative test for detecting severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) antigen. Although the positive predictive value of the test is high, false\u2010positive (FP) results are unavoidable. Furthermore, FP results can lead to unnecessary isolation of patients or exposure of FP patients to truly positive patients. Therefore, to minimize potential harm to FP patients, this study aimed to identify clinical cases that are likely to produce FP results and in which additional testing should be recommended. These recommendations should be based on the Elecsys test results and relevant clinical information. Correspondingly, a retrospective study was conducted using nasopharyngeal swab samples from symptomatic and asymptomatic patients with SARS\u2010CoV\u20102 infection and patients who had close contact with a confirmed SARS\u2010CoV\u20102 infection case between September 2021 and October 2023. Of the total 5989 samples, 302 tested positive in the Elecsys test. Thereafter, the reverse transcription\u2010polymerase chain reaction test was performed on patient samples (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200954) with positive Elecsys test results without clinical information consistent with coronavirus disease 19 (COVID\u201019). A total of 37 of these samples were FP results, and all FP samples showed Elecsys test values near the cutoff index (COI) value. Accordingly, when the Elecsys test yields a low COI value, and the clinical presentation is inconsistent with COVID\u201019, additional confirmatory testing is recommended.\n                  <\/jats:p>","DOI":"10.1155\/cjid\/9054868","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T05:44:41Z","timestamp":1763790281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interpretation of Positive Roche Elecsys SARS\u2010CoV\u20102 Antigen Test Results: Value for Clinical Decisions"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0193-4916","authenticated-orcid":false,"given":"Shinsuke","family":"Mizuno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Tsukamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"e_1_2_11_1_2","unstructured":"Ministry of HealthandLabour and Welfare List of Authorized In Vitro Diagnostics (IVDs) for COVID-19 2023 https:\/\/www.mhlw.go.jp\/stf\/newpage_11332.html."},{"key":"e_1_2_11_2_2","unstructured":"Pharmaceutical Safety Division Ministry of Health Labor andand Welfare (MLHW) Approval of Diagnostic Test for SARS-CoV-2 Infection (Lumipulse G SARS-CoV-2 Ag) 2020 https:\/\/www.pmda.go.jp\/files\/000235412.pdf."},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2021.06.019"},{"key":"e_1_2_11_4_2","unstructured":"Ministry of Health Labor andWelfare (MHLW) Clinical Management of Patients With COVID-19 2022 https:\/\/www.mhlw.go.jp\/content\/000936655.pdf."},{"key":"e_1_2_11_5_2","unstructured":"Roche Diagnostics Roche Diagnostics Gmbh Immunoassay Elecsys\u00ae Anti-SARS-CoV-2 Instructions for Use 2020 https:\/\/diagnostics.roche.com\/jp\/ja\/products\/params\/elecsys-sars-cov-2-antigen-test.html."},{"key":"e_1_2_11_6_2","unstructured":"Biom\u00e9rieux Biofire\u00ae Filmarray\u00ae Respiratory Panel 2.1 (RP2.1) 2023 https:\/\/www.biofiredx.qarad.eifu.online\/ITI\/JP\/all?keycode=ITI0105."},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-021-00719-0"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27412"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2021.102127"},{"key":"e_1_2_11_10_2","unstructured":"National Institute of Infectious Diseases 20220925_Genome_Weekly_Lineagejapan 2022 https:\/\/www.mhlw.go.jp\/stf\/covid-19\/kokunainohasseijoukyou.html."},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18611-5"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23906"}],"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cjid\/9054868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/cjid\/9054868","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cjid\/9054868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:25:19Z","timestamp":1773008719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/cjid\/9054868"}},"subtitle":[],"editor":[{"given":"Mahmoud","family":"Elhaig","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/cjid\/9054868"],"URL":"https:\/\/doi.org\/10.1155\/cjid\/9054868","archive":["Portico"],"relation":{},"ISSN":["1712-9532","1918-1493"],"issn-type":[{"value":"1712-9532","type":"print"},{"value":"1918-1493","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9054868"}}