{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:42:47Z","timestamp":1773013367743,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T00:00:00Z","timestamp":1754784000000},"content-version":"vor","delay-in-days":221,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000190","name":"University of Alberta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    In clinical trials, pre\u2010exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate\u2010emtricitabine (TDF\/FTC) or tenofovir alafenamide\u2010emtricitabine (TAF\/FTC) is up to 99% efficacious in preventing human immunodeficiency virus (HIV) infection. The real\u2010world effectiveness of PrEP has not been extensively evaluated in Canada.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    This population\u2010based cohort included adults without HIV as determined by viral serology and ICD\u20109\/ICD\u201010 codes from Alberta with \u2265 3\u2009months of PrEP prescriptions. It used provincial administrative data. Patients were followed from their first PrEP prescription until diagnosed HIV infection or censoring. Cox proportional hazard models were used to identify independent predictors of HIV infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 4750 adults with a mean (SD) age of 35.9 (11) years of which 8% were female were prescribed PrEP including TDF\/FTC (97.5%) or TAF\/FTC (2.5%). There were 335 HIV infections (92.9% effectiveness) over median cohort follow\u2010up of 1.0\u2009years (IQR 1.9) with 4.89 (95% CI 4.38, 5.44) HIV infections per 100 patient years. Age (HR 1.04, 95% CI 1.03\u20131.05 per 1\u2009year increase), male sex (HR 0.34, 95% CI 0.27\u20130.44), CKD Stage G3 (HR 2.39, 95% CI 1.82, 3.14), SES (4th and 5th quintiles versus 1st quintile), drug use (HR 2.11, 95% 1.45, 3.08), and history of STI (HR 0.45, 95% CI 0.29, 0.72) were independent predictors of HIV infection. The HIV incidence decreased to 1.5 (95% CI 1.2, 1.8) and 0.6 (95% CI 0.4, 0.9) per 100 patient years in cohorts with negative baseline HIV serology with 180 and 30\u2009days prior to index PrEP prescription.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    HIV PrEP appears to be effective for preventing HIV infection in this real\u2010world population\u2010based study in Alberta, Canada. Strategies to mitigate residual HIV risk in PrEP users are needed.\n                  <\/jats:p>","DOI":"10.1155\/cjid\/9340622","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T05:35:24Z","timestamp":1754890524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Real\u2010World Effectiveness of Human Immunodeficiency Virus Pre\u2010Exposure Prophylaxis in Adults in Alberta, Canada: A Retrospective Population\u2010Based Cohort Study"],"prefix":"10.1155","volume":"2025","author":[{"given":"Elissa","family":"Rennert May","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon L.","family":"Turvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek S.","family":"Chew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Tonelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Klarenbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neesh","family":"Pannu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Christie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aminu","family":"Bello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caley B.","family":"Shukalek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raynell","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2323-6521","authenticated-orcid":false,"given":"David","family":"Collister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,10]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011205"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108524"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61127-7"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506273"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31065-5"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00056-2"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.170494"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17025"},{"key":"e_1_2_10_9_2","unstructured":"Preexposure Prophylaxis for the Prevention of HIV Infection in the United States\u20132021 Update Clinical Practice Guideline 1-108."},{"key":"e_1_2_10_10_2","volume-title":"TRUVADA (Emtricitabine\/Tenofovir Disoproxil Fumarate) Tablets (200 mg\/300 mg) Antiretroviral Agent PRODUCT MONOGRAPH","author":"Gilead Sciences Canada Imlnwc","year":"2018"},{"key":"e_1_2_10_11_2","first-page":"1","article-title":"ON L5N 2W3. 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